RAMP3 and CALCRL

Number of citations of the paper that reports this interaction (PubMedID 11387328)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RAMP3	CALCRL
Description		receptor activity modifying protein 3	calcitonin receptor like receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cell Lysosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Amylin Receptor Complex 3 Adrenomedullin Receptor Complex	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex
	Molecular Function	Amyloid-beta Binding Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding
	Biological Process	Angiogenesis Positive Regulation Of Receptor Recycling Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of Cell Death Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Estradiol Stimulus Protein Localization To Plasma Membrane G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Amylin Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Response To Amyloid-beta Positive Regulation Of Calcium Ion Import Across Plasma Membrane Adrenomedullin Receptor Signaling Pathway	Angiogenesis Calcium Ion Transport Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Protein Transport Receptor Internalization Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Pramlintide	Olcegepant Telcagepant
Diseases
GWAS		Hepatic lipid content in extreme obesity ( 25246029)	Body mass index ( 25673413) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Resting heart rate ( 27798624) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		10 interacting genes: CALCR CALCRL HSPB3 KRTAP10-3 KRTAP5-9 NOTCH2NLA NSF PDCD6IP SLC31A2 VIPR1	6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		10268	10203
HPRD ID		05517	11809
Ensembl ID		ENSG00000122679	ENSG00000064989
Uniprot IDs		A4D2L1 O60896	D3DPG9 Q16602
PDB IDs			3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y
Enriched GO Terms of Interacting Partners?
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