CALCRL and RAMP2

Number of citations of the paper that reports this interaction (PubMedID 9620797)
397

Data Source:
HPRD (in vitro)

		CALCRL	RAMP2
Description		calcitonin receptor like receptor	receptor activity modifying protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex	Cell Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Cell Surface Receptor Complex Amylin Receptor Complex 2 Adrenomedullin Receptor Complex
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Adrenomedullin Binding
	Biological Process	Angiogenesis Calcium Ion Transport Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Protein Transport Receptor Internalization Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Development Amylin Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Olcegepant Telcagepant	Pramlintide
Diseases
GWAS		Body mass index ( 25673413) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Resting heart rate ( 27798624) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Pulse pressure ( 30224653)
Interacting Genes		6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3	5 interacting genes: CALCA CALCRL IAPP SLC31A2 VIPR1
Entrez ID		10203	10266
HPRD ID		11809	05516
Ensembl ID		ENSG00000064989	ENSG00000131477
Uniprot IDs		D3DPG9 Q16602	A0A024R1Z2 O60895
PDB IDs		3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y	2XVT 3AQE 3AQF 4RWF
Enriched GO Terms of Interacting Partners?
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