CNKSR1 and RASSF1

Number of citations of the paper that reports this interaction (PubMedID 15075335)
29

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (two hybrid, in vivo)

		CNKSR1	RASSF1
Description		connector enhancer of kinase suppressor of Ras 1	Ras association domain family member 1
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton
	Molecular Function	Protein Binding Protein Binding, Bridging	Protein Binding Zinc Ion Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Cell Cycle Arrest Ras Protein Signal Transduction Regulation Of Microtubule Cytoskeleton Organization
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases			Non-small cell lung cancer Bladder cancer Nasopharyngeal cancer
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698)
Interacting Genes		19 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 ZDHHC17	70 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SAV1 SMARCA4 STK11 STK3 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA
Entrez ID		10256	11186
HPRD ID		11937	05470
Ensembl ID		ENSG00000142675	ENSG00000068028
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q9NS23
PDB IDs		1WWV	2KZU
Enriched GO Terms of Interacting Partners?
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