RASSF1 and ATP2B4

Number of citations of the paper that reports this interaction (PubMedID 15145946)
25

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		RASSF1	ATP2B4
Description		Ras association domain family member 1	ATPase plasma membrane Ca2+ transporting 4
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton	Cell Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Basolateral Plasma Membrane Z Disc T-tubule Protein-containing Complex Sperm Flagellum Neuron Projection Intracellular Membrane-bounded Organelle Membrane Raft Sperm Principal Piece Glutamatergic Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Protein Binding Zinc Ion Binding	Calcium-transporting ATPase Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Sodium Channel Regulator Activity Cation-transporting ATPase Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Cell Cycle Arrest Ras Protein Signal Transduction Regulation Of Microtubule Cytoskeleton Organization	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Cellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Negative Regulation Of Nitric Oxide Mediated Signal Transduction Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases		Non-small cell lung cancer Bladder cancer Nasopharyngeal cancer
GWAS		Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698)	Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Hemoglobin concentration ( 27863252) Lymphocyte counts ( 27863252) Malaria ( 22895189) Mean corpuscular hemoglobin concentration ( 23263863 28453575 27863252) Mean corpuscular volume ( 27863252) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Red cell distribution width ( 27863252 28957414)
Interacting Genes		70 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SAV1 SMARCA4 STK11 STK3 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA	11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC
Entrez ID		11186	493
HPRD ID		05470	00159
Ensembl ID		ENSG00000068028	ENSG00000058668
Uniprot IDs		Q9NS23	A0A024R968 P23634
PDB IDs		2KZU	1CFF 2KNE
Enriched GO Terms of Interacting Partners?
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