STAM2 and SH2D4A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		STAM2	SH2D4A
Description		signal transducing adaptor molecule 2	SH2 domain containing 4A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Phosphatase Binding Signaling Adaptor Activity
	Biological Process	Intracellular Protein Transport Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Positive Regulation Of Signal Transduction Negative Regulation Of Phosphatase Activity
Pathways		EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)	Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)
Interacting Genes		35 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1	44 interacting genes: ALAS1 CASK CCDC172 CDR2 CEP70 CEP76 DBNL FSD2 GOLGA2 GRB2 HCLS1 HMBOX1 IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PNMA1 PPP1CB PSTPIP1 RINT1 SH3GL1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 UBXN11 USHBP1 VPS52 ZBTB16
Entrez ID		10254	63898
HPRD ID		05876	08340
Ensembl ID		ENSG00000115145	ENSG00000104611
Uniprot IDs		O75886	Q9H788
PDB IDs		1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?