STAM2 and TYK2

Number of citations of the paper that reports this interaction (PubMedID 10899310)
18

Data Source:
HPRD (in vivo, in vitro)

		STAM2	TYK2
Description		signal transducing adaptor molecule 2	tyrosine kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Intracellular Protein Transport Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-27-mediated Signaling Pathway
Pathways		EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs			2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Tofacitinib
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 25751624 19966805) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)
Interacting Genes		35 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1	37 interacting genes: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5
Entrez ID		10254	7297
HPRD ID		05876	01490
Ensembl ID		ENSG00000115145	ENSG00000105397
Uniprot IDs		O75886	A0A024R7E4 P29597
PDB IDs		1X2Q 1X5B 2L0T 5CRV 5IXF	3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR
Enriched GO Terms of Interacting Partners?
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