SH2D4A and SORBS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SH2D4A	SORBS2
Description		SH2 domain containing 4A	sorbin and SH3 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatase Binding Signaling Adaptor Activity	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Structural Constituent Of Muscle
	Biological Process	Positive Regulation Of Signal Transduction Negative Regulation Of Phosphatase Activity	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development
Pathways
Drugs
Diseases
GWAS		Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Cardiac Troponin-T levels ( 31014085) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) Short-term memory (digit-span task) ( 30741946) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		44 interacting genes: ALAS1 CASK CCDC172 CDR2 CEP70 CEP76 DBNL FSD2 GOLGA2 GRB2 HCLS1 HMBOX1 IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PNMA1 PPP1CB PSTPIP1 RINT1 SH3GL1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 UBXN11 USHBP1 VPS52 ZBTB16	37 interacting genes: ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL DLGAP1 DLGAP2 DLGAP4 EFS EGFR FAT1 FLOT1 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SYNJ1 TRAF4 VCL VPS37C WAS WASF1 YWHAE YWHAZ
Entrez ID		63898	8470
HPRD ID		08340	12473
Ensembl ID		ENSG00000104611	ENSG00000154556
Uniprot IDs		Q9H788	B7Z3D7 B7Z997 O94875
PDB IDs			5VEI
Enriched GO Terms of Interacting Partners?
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