CDK6 and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDK6	MAP2K3
Description		cyclin dependent kinase 6	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin D2-CDK6 Complex	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding FBXO Family Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Activation Of MAPK Activity Inflammatory Response Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Alvocidib (2S)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol 3,7,3',4'-TETRAHYDROXYFLAVONE Palbociclib Ribociclib Abemaciclib
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diastolic blood pressure ( 30578418) Eosinophil counts ( 29403010 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 18391950 18391951 18391952) Hip circumference adjusted for BMI ( 28552196 25673412) Ischemic stroke ( 29531354) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular volume ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 25096241 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Pulse pressure ( 27841878 27618447 30578418) Red blood cell count ( 29403010) Rheumatoid arthritis ( 30423114 18794853 24390342) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Total cholesterol levels ( 30275531) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Weight ( 28552196) White blood cell count ( 25096241 29403010 20139978 27863252 21738479) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Body mass index ( 26426971 28892062)
Interacting Genes		131 interacting genes: ABI2 AKT1 ANKRD12 AR ARAF ARNT ATF6B ATXN1 BCL11A BECN1 CASC3 CBLC CBY1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC6 CDK4 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 ELOA2 EPHA2 ERBB2 EZH2 FGFR4 FOXM1 FOXO3 FZR1 GLIS1 GLIS2 GRM1 H1-1 HGF HIF1A HSF1 ISL1 KAT2A KDELR2 KEAP1 KIF26B KLF10 LATS2 LPIN1 MAP2K3 MAP2K5 MAP3K5 MAPK14 MCM10 MCM2 MEF2D MET MLLT3 MSL3 MYC MZF1 N4BP1 NF2 NFATC3 NIPBL NUMA1 PCNA PDGFRA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RAF1 RASSF1 RB1 RBL1 RBL2 RBM23 RBPMS RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 STK11 SUMO1 SYNPO2 TEAD2 TERT TFDP1 TGFBR1 TJP2 TNFRSF1A TP53 TPX2 TRA2A TRA2B TRAK1 TSC1 UHRF2 USP17L2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	55 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		1021	5606
HPRD ID		04533	03816
Ensembl ID		ENSG00000105810	ENSG00000034152
Uniprot IDs		Q00534	P46734 Q6FI23
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5 4TTH 5L2I 5L2S 5L2T
Enriched GO Terms of Interacting Partners?
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