CDK6 and RBPMS

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		CDK6	RBPMS
Description		cyclin dependent kinase 6	RNA binding protein, mRNA processing factor
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin D2-CDK6 Complex	P-body Nucleoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding FBXO Family Protein Binding	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Poly(A) Binding Protein Homodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	RNA Processing Response To Oxidative Stress Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Drugs		Alvocidib (2S)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol 3,7,3',4'-TETRAHYDROXYFLAVONE Palbociclib Ribociclib Abemaciclib
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diastolic blood pressure ( 30578418) Eosinophil counts ( 29403010 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 18391950 18391951 18391952) Hip circumference adjusted for BMI ( 28552196 25673412) Ischemic stroke ( 29531354) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular volume ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 25096241 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Pulse pressure ( 27841878 27618447 30578418) Red blood cell count ( 29403010) Rheumatoid arthritis ( 30423114 18794853 24390342) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Total cholesterol levels ( 30275531) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Weight ( 28552196) White blood cell count ( 25096241 29403010 20139978 27863252 21738479) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Blood urea nitrogen levels ( 31152163) Breast size ( 27182965) Granulocyte count ( 27863252) Heart rate variability traits ( 22174390) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular volume ( 29403010 27863252 28017375) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Platelet count ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Total grey matter volume ( 31530798)
Interacting Genes		131 interacting genes: ABI2 AKT1 ANKRD12 AR ARAF ARNT ATF6B ATXN1 BCL11A BECN1 CASC3 CBLC CBY1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC6 CDK4 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 ELOA2 EPHA2 ERBB2 EZH2 FGFR4 FOXM1 FOXO3 FZR1 GLIS1 GLIS2 GRM1 H1-1 HGF HIF1A HSF1 ISL1 KAT2A KDELR2 KEAP1 KIF26B KLF10 LATS2 LPIN1 MAP2K3 MAP2K5 MAP3K5 MAPK14 MCM10 MCM2 MEF2D MET MLLT3 MSL3 MYC MZF1 N4BP1 NF2 NFATC3 NIPBL NUMA1 PCNA PDGFRA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RAF1 RASSF1 RB1 RBL1 RBL2 RBM23 RBPMS RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 STK11 SUMO1 SYNPO2 TEAD2 TERT TFDP1 TGFBR1 TJP2 TNFRSF1A TP53 TPX2 TRA2A TRA2B TRAK1 TSC1 UHRF2 USP17L2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	210 interacting genes: ABCF3 ADAM15 AMMECR1 ANKMY1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0D1 ATP6V0E2 ATXN1 BANP BBS2 BCL6B BHLHE40 BOLL C11orf87 C1orf94 C22orf39 C9orf24 CAMK2B CCER1 CCNG1 CCNK CDC23 CDC42EP1 CDK6 CHCHD7 CNNM3 CRBN CREB5 CRX CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DMRT3 DMRTB1 DOK3 DOK6 DPYSL4 DTX2 DVL2 EAF2 EFEMP2 ENKD1 EWSR1 EXOSC1 EYA2 FAM124B FAM168A FASTK FBF1 FBXL18 FNDC11 FOXC2 FOXP3 FOXS1 FRG1 FXR2 GATA1 GATAD2B GCM2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 GTF2F2 HEY2 HEYL HNRNPLL HOXA1 HOXA9 HOXB9 HOXC8 HSFY1 IGF2 ILF3 INCA1 INIP IP6K2 KCTD9 KIF1A KIR2DL4 KPNA2 KRAS KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP8-1 LASP1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LINC01869 LMO4 LONRF1 LRRC41 LZTS2 MAGED1 MCM5 MCM7 MEIS2 MGAT5B MKRN3 MORN3 MRPL20-AS1 MVP MYOZ2 NAB2 NANOG NAPRT NEDD9 NEU4 NR1D2 NTAQ1 NYNRIN OTX1 PATZ1 PDLIM4 PER1 PGLS PHF1 PICALM PIH1D1 PIN1 PITX1 PLAC8 POGZ POLR3GL POM121 PPP1R16B PRKAA1 PRKAA2 PRKAB2 PRR20A PSMF1 QKI R3HDM2 RABL6 RAD54L2 RAMAC RBFOX1 RBFOX2 RBM46 RDH12 RHOBTB3 RHOXF2 RIPPLY1 ROR2 RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SFI1 SH3RF2 SIRPB1 SMAD3 SMUG1 SNHG29 SNRPB SNRPC SPATA46 SPATA8 SPG7 STRBP TBX6 TCF7L2 TENT2 TEX37 TFG TIE1 TINAGL1 TLE5 TMSB4X TNS2 TOLLIP TOR1AIP2 TRAF4 TRIP13 TSG101 TTLL10 TUSC2 UBXN8 VENTX VHL VHLL VPS37C WDR54 WDR90 YPEL3 ZBTB32 ZC3H10 ZNF385C ZNF488 ZNF581
Entrez ID		1021	11030
HPRD ID		04533	11870
Ensembl ID		ENSG00000105810	ENSG00000157110
Uniprot IDs		Q00534	B4E3T4 D3DSV0 Q93062
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5 4TTH 5L2I 5L2S 5L2T	1BNY 5CYJ 5DET
Enriched GO Terms of Interacting Partners?
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