EIF1 and RASA1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		EIF1	RASA1
Description		eukaryotic translation initiation factor 1	RAS p21 protein activator 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic 43S Preinitiation Complex	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Dosage Compensation By Inactivation Of X Chromosome	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways			Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS			Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: APP EIF4G1 HMGB1 HMGB2 MAPK6 OLFM2 RASA1 UPF2	75 interacting genes: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RACK1 RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		10209	5921
HPRD ID		15449	00745
Ensembl ID		ENSG00000173812	ENSG00000145715
Uniprot IDs		P41567 Q6IAV3	P20936 Q59GK3
PDB IDs		2IF1 4KZX 4KZY	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?
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