OCLN and SYNE4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		OCLN	SYNE4
Description		occludin	spectrin repeat containing nuclear envelope family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction	Integral Component Of Nuclear Outer Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Cell-cell Junction Organization Positive Regulation Of Glucose Import Protein-containing Complex Assembly Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Tumor Necrosis Factor Positive Regulation Of Wound Healing Protein Localization To Cell Leading Edge Positive Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Regulation Of Bicellular Tight Junction Assembly	Establishment Of Epithelial Cell Apical/basal Polarity
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS		Interleukin-18 levels ( 27989323)
Interacting Genes		10 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 PTPN2 SNW1 SYNE4 TJP1 TNFAIP3 ULK1	51 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250
Entrez ID		100506658	163183
HPRD ID			08776
Ensembl ID		ENSG00000197822	ENSG00000181392
Uniprot IDs		A8K3T2 Q16625	Q8N205
PDB IDs		1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?