CHAF1A and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 21209461)
13

Data Source:
BioGRID (pull down, pull down)

		CHAF1A	XRCC6
Description		chromatin assembly factor 1 subunit A	X-ray repair cross complementing 6
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Protein-containing Complex CAF-1 Complex	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding	DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Cyclin Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Cell Cycle Chromatin Assembly	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways			2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red cell distribution width ( 27863252 28957414)	Breast cancer ( 29059683) Neuroticism ( 29255261) Pulse pressure ( 28135244)
Interacting Genes		39 interacting genes: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B CREBBP DBF4 DDX41 H3-4 H3C6 HMGB2 LZTR1 MBD1 MSH6 PABPC1 PCBD2 PCNA RBFOX2 REL SET SPOP SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408	131 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TOP1 TP53 UBC VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		10036	2547
HPRD ID		03148	01071
Ensembl ID		ENSG00000167670	ENSG00000196419
Uniprot IDs		Q13111	A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956
PDB IDs			1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH
Enriched GO Terms of Interacting Partners?
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