CDC25A and DUSP8

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CDC25A	DUSP8
Gene Name		cell division cycle 25A	dual specificity phosphatase 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Cell Proliferation Response To Radiation Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle	Inactivation Of MAPK Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		E2F mediated regulation of DNA replication Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M Checkpoints G2/M Transition G0 and Early G1 Cyclin E associated events during G1/S transition S Phase Cyclin B2 mediated events Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Activation of ATR in response to replication stress G1/S-Specific Transcription E2F-enabled inhibition of pre-replication complex formation p53-Independent DNA Damage Response Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry p53-Independent G1/S DNA damage checkpoint Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		52 interactors: ANAPC11 APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NFKBIB NFYA PEX19 PIM1 POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	2 interactors: CDC25A MAPK8
Entrez ID		993	1850
HPRD ID		00305	03617
Ensembl ID		ENSG00000164045	ENSG00000184545
Uniprot IDs		P30304	Q13202
PDB IDs		1C25
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Growth Factor Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Cell Death Death Regulation Of Gene Expression Regulation Of Protein Catabolic Process Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Catalytic Activity Response To Stimulus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process	Response To UV Response To Light Stimulus Response To Radiation JUN Phosphorylation Positive Regulation Of Deacetylase Activity Positive Regulation Of Determination Of Dorsal Identity Cellular Response To Nitric Oxide Response To Nitric Oxide Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Reactive Nitrogen Species Response To Abiotic Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Histone Deacetylation Programmed Necrotic Cell Death Peptidyl-threonine Phosphorylation Necrotic Cell Death Regulation Of Protein Deacetylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Protein Binding Response To Cadmium Ion Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Mitochondrion Organization Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Cellular Response To UV Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process JNK Cascade Cellular Response To Light Stimulus Regulation Of Mitochondrion Organization Regulation Of Circadian Rhythm Negative Regulation Of Binding Cellular Response To Reactive Oxygen Species Regulation Of Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity
Tagcloud ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	adamts1 adrenomedulin affymetrix aorta augment chelators coupling dups1 dusp10 dusp16 elevation employing endoperoxide excitation fos hela hes1 huvec metallopeptidase na nfkbia ouabain profound prostaglandin rvsmc transcriptomes transcriptomic ubiquitous umbilical
Tagcloud (Difference) ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	adamts1 adrenomedulin affymetrix aorta augment chelators coupling dups1 dusp10 dusp16 elevation employing endoperoxide excitation fos hela hes1 huvec metallopeptidase na nfkbia ouabain profound prostaglandin rvsmc transcriptomes transcriptomic ubiquitous umbilical
Tagcloud (Intersection) ?