GIT2 and ATF5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GIT2	ATF5
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 2	activating transcription factor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Corepressor Activity Protein Binding Heat Shock Protein Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Behavioral Response To Pain	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Post-embryonic Development Olfactory Bulb Interneuron Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148) Metabolite levels (MHPG) ( 23319000)
Protein-Protein Interactions		44 interactors: ACTG1 ACTN1 ADRBK1 ARHGEF7 ATF5 C4BPA CALCOCO2 CORO1A E2F2 EDC4 GCH1 GIT1 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	12 interactors: ATXN1 CCND3 CD34 CDC34 CEBPA CEBPE CEBPG DISC1 EP300 GABBR1 GABBR2 GIT2
Entrez ID		9815	22809
HPRD ID		09779	05906
Ensembl ID		ENSG00000139436	ENSG00000169136
Uniprot IDs		F8VXI9 Q14161 Q6FI58	Q9Y2D1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Ephrin Receptor Signaling Pathway Innate Immune Response Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of Immune System Process Cell Death Regulation Of Metabolic Process Death Positive Regulation Of Immune Response Defense Response Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Adherens Junction Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Focal Adhesion Assembly Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Signaling Regulation Of Kinase Activity Cellular Component Assembly Cell Communication Regulation Of Phosphorylation Adherens Junction Assembly Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Development Cell-substrate Junction Assembly Activation Of MAPK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Stress Activation Of Innate Immune Response Cell Surface Receptor Signaling Pathway	Response To Stimulus Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Macrophage Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Regulation Of Cellular Response To Heat Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Hemopoiesis Organ Development Myeloid Cell Differentiation Lung Development Respiratory Tube Development Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Immune System Development Immune System Process Respiratory System Development Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Histone H2B Acetylation Positive Regulation Of Glial Cell Line-derived Neurotrophic Factor Secretion Negative Regulation Of Cellular Response To Heat Extracellular Vesicular Exosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cell-cell Signaling Regulation Of CAMP Biosynthetic Process Positive Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cellular Response To Hypoxia Mesangial Cell-matrix Adhesion Positive Regulation Of Granulocyte Colony-stimulating Factor Production Regulation Of CAMP Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Macrophage Colony-stimulating Factor Production Vascular Wound Healing N-terminal Peptidyl-lysine Acetylation Myeloid Leukocyte Differentiation
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	1beta activate cascades ccaat consistently cooperated ebp ebps effector elusive enhancer initiates interacted knockout luciferase mimicked nemo nlk opposite potentiated proinflammatory propagates proteasome screen stabilization stabilize tak1 though triggered
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	1beta activate cascades ccaat consistently cooperated ebp ebps effector elusive enhancer initiates interacted knockout luciferase mimicked nemo nlk opposite potentiated proinflammatory propagates proteasome screen stabilization stabilize tak1 though triggered
Tagcloud (Intersection) ?