CD44 and MSN

Number of citations of the paper that reports this interaction (PMID 9472040)
122

Data Source:
BioGRID (pull down)

		CD44	MSN
Gene Name		CD44 molecule (Indian blood group)	moesin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Macrophage Migration Inhibitory Factor Receptor Complex Extracellular Vesicular Exosome	Uropod Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium Microvillus Membrane Vesicle Apical Part Of Cell Extracellular Vesicular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Hyalurononglucosaminidase Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Double-stranded RNA Binding Actin Binding Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Wound Healing Involved In Inflammatory Response Carbohydrate Metabolic Process Cell-matrix Adhesion Blood Coagulation Pathogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Movement Of Cell Or Subcellular Component Leukocyte Cell-cell Adhesion Positive Regulation Of Gene Expression Membrane To Membrane Docking Leukocyte Migration Establishment Of Endothelial Barrier Regulation Of Lymphocyte Migration
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Hyaluronan uptake and degradation Interferon gamma signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Interferon Signaling Defective CHST3 causes SEDCJD Cytokine Signaling in Immune system Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Cell surface interactions at the vascular wall MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Axon guidance L1CAM interactions Recycling pathway of L1
Drugs		Hyaluronan
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Vitiligo ( 22561518)
Protein-Protein Interactions		39 interactors: ANK1 ARHGEF1 ARHGEF12 CD4 CD74 COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 ERBB4 EZR FGF2 FN1 FYN GARS HBEGF HMMR IGFBP3 LCK MADCAM1 MMP1 MMP7 MMP9 MSN NF2 PKN1 SELE SPP1 SRC SRGN TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	24 interactors: BCAP31 CD44 CD46 CD93 CDK11B EZR ICAM1 ICAM2 ICAM3 L1CAM NCF1 NCF4 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SPN TERF1 TSC1 VCAM1
Entrez ID		960	4478
HPRD ID		00115	02399
Ensembl ID		ENSG00000026508	ENSG00000147065
Uniprot IDs		P16070	P26038
PDB IDs		1POZ 1UUH 2I83	1E5W 1EF1 1SGH
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Wound Healing Immune System Process Leukocyte Migration Regulation Of Cellular Component Movement Response To Wounding Anatomical Structure Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway System Development Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Motility Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Locomotion Cell Differentiation Regulation Of Cell Migration Multicellular Organismal Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Extracellular Matrix Disassembly Tissue Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Organ Development Platelet Activation Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Cell Motility Response To Stress Cell Adhesion Neurogenesis Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Nervous System Development Single Organismal Cell-cell Adhesion	Membrane To Membrane Docking Single Organismal Cell-cell Adhesion Cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Cellular Extravasation Membrane Docking Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Cell-cell Adhesion Locomotion Regulation Of Immune System Process Regulation Of T Cell Proliferation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Execution Phase Of Apoptosis Cell Migration Regulation Of Cell-cell Adhesion Cell Motility Positive Regulation Of T Cell Activation Cell Surface Receptor Signaling Pathway Immune Response Apoptotic Process Blood Coagulation Inflammatory Response Hemostasis Cell Activation Programmed Cell Death Cell Death Death Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Signal Transduction Leukocyte Activation Interferon-gamma-mediated Signaling Pathway Response To Stimulus Regulation Of T Cell Activation Innate Immune Response Positive Regulation Of Cell Activation Negative Regulation Of Signaling Cellular Response To Interferon-gamma Regulation Of Body Fluid Levels
Tagcloud ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	assignments cen discordancy est00675 est00745 est00795 est00887 est00896 est01041 est01471 est01583 est01627 est01650 est01678 est01744 ests globule l18a l1a l1b moesin multiplexed s14 subregionally sulfurtransferase thiosulfate transhydrogenase xp11 xpter
Tagcloud (Difference) ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	assignments cen discordancy est00675 est00745 est00795 est00887 est00896 est01041 est01471 est01583 est01627 est01650 est01678 est01744 ests globule l18a l1a l1b moesin multiplexed s14 subregionally sulfurtransferase thiosulfate transhydrogenase xp11 xpter
Tagcloud (Intersection) ?