CD44 and DMP1

Number of citations of the paper that reports this interaction (PMID 11825898)
20

Data Source:
HPRD (in vitro)

		CD44	DMP1
Gene Name		CD44 molecule (Indian blood group)	dentin matrix acidic phosphoprotein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Macrophage Migration Inhibitory Factor Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Nucleus Nucleoplasm Nucleolus Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Hyalurononglucosaminidase Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Integrin Binding Calcium Ion Binding Extracellular Matrix Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Wound Healing Involved In Inflammatory Response Carbohydrate Metabolic Process Cell-matrix Adhesion Blood Coagulation Pathogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Ossification Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Biomineral Tissue Development
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Hyaluronan uptake and degradation Interferon gamma signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Interferon Signaling Defective CHST3 causes SEDCJD Cytokine Signaling in Immune system Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Cell surface interactions at the vascular wall MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	ECM proteoglycans
Drugs		Hyaluronan
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Vitiligo ( 22561518)	Dental caries ( 23064961)
Protein-Protein Interactions		39 interactors: ANK1 ARHGEF1 ARHGEF12 CD4 CD74 COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 ERBB4 EZR FGF2 FN1 FYN GARS HBEGF HMMR IGFBP3 LCK MADCAM1 MMP1 MMP7 MMP9 MSN NF2 PKN1 SELE SPP1 SRC SRGN TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	2 interactors: CD44 CFH
Entrez ID		960	1758
HPRD ID		00115	02989
Ensembl ID		ENSG00000026508	ENSG00000152592
Uniprot IDs		P16070	Q13316
PDB IDs		1POZ 1UUH 2I83
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Wound Healing Immune System Process Leukocyte Migration Regulation Of Cellular Component Movement Response To Wounding Anatomical Structure Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway System Development Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Motility Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Locomotion Cell Differentiation Regulation Of Cell Migration Multicellular Organismal Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Extracellular Matrix Disassembly Tissue Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Organ Development Platelet Activation Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Cell Motility Response To Stress Cell Adhesion Neurogenesis Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Nervous System Development Single Organismal Cell-cell Adhesion	Positive Regulation Of Monocyte Aggregation Monocyte Aggregation Regulation Of Protein Processing Wound Healing Involved In Inflammatory Response Positive Regulation Of Heterotypic Cell-cell Adhesion Complement Activation, Alternative Pathway Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Hyaluronan Catabolic Process Innate Immune Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Branching Involved In Prostate Gland Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Complement Activation Immune Response Defense Response Prostate Gland Epithelium Morphogenesis Hyaluronan Metabolic Process Prostate Gland Morphogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Humoral Immune Response Glycosaminoglycan Catabolic Process Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Prostate Gland Development Regulation Of Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Nephron Morphogenesis Renal Tubule Morphogenesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Extracellular Matrix Disassembly Renal Tubule Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Immune System Process Kidney Morphogenesis Regulation Of Protein Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Interferon-gamma-mediated Signaling Pathway Mesonephros Development Regulation Of Response To DNA Damage Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Complement Activation Nephron Development
Tagcloud ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	7q21 adenosquamous alternatively deleted deposits diminishing dmp1alpha dmp1beta dmp1gamma haplo hemizygously hyperplasia indeed insufficient keratinized locus mmtv multifocal publicly seq spliced splicing surrounding transdifferentiation tumour tumourigenic tumours undefined upregulating
Tagcloud (Difference) ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	7q21 adenosquamous alternatively deleted deposits diminishing dmp1alpha dmp1beta dmp1gamma haplo hemizygously hyperplasia indeed insufficient keratinized locus mmtv multifocal publicly seq spliced splicing surrounding transdifferentiation tumour tumourigenic tumours undefined upregulating
Tagcloud (Intersection) ?