HAND2 and HEYL

Number of citations of the paper that reports this interaction (PMID 10924525)
22

Data Source:
HPRD (two hybrid, in vitro)

		HAND2	HEYL
Gene Name		heart and neural crest derivatives expressed 2	hes-related family bHLH transcription factor with YRPW motif-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex Protein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription AT DNA Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Protein Homodimerization Activity Protein Heterodimerization Activity AF-1 Domain Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Thymus Development Peripheral Nervous System Neuron Development Palate Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis	Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Mesenchymal Cell Development Glomerulus Development Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To BMP Stimulus Proximal Tubule Development Negative Regulation Of Androgen Receptor Activity
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Red blood cell traits ( 23222517)
Protein-Protein Interactions		14 interactors: CENPB COPS5 EP300 GATA4 HAND1 HEY2 HEYL NPM1 PHOX2A PPP2R5D PRKACA PRKCA TCF3 TCF4	18 interactors: APP ATF7IP ATXN1 HAND1 HAND2 HIPK3 HTT LAPTM5 MDFI PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B
Entrez ID		9464	26508
HPRD ID		03872	16419
Ensembl ID		ENSG00000164107	ENSG00000163909
Uniprot IDs		P61296	F5H3V9 Q9NQ87
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Cardiovascular System Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cardiac Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Ventricle Morphogenesis Tissue Development Anatomical Structure Morphogenesis Cardiac Right Ventricle Morphogenesis Atrioventricular Valve Morphogenesis Regulation Of Metabolic Process Cardiac Septum Development Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Atrioventricular Valve Development Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Binding Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Regulation Of Cell Cycle Organ Development Striated Muscle Tissue Development Heart Valve Morphogenesis Heart Valve Development Muscle Tissue Development Transcription, DNA-templated Histone H3-T6 Phosphorylation Tissue Morphogenesis Epithelium Development System Development Energy Reserve Metabolic Process Cardiac Chamber Development RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Embryo Development Regulation Of Nucleic Acid-templated Transcription Tube Development Regulation Of RNA Biosynthetic Process Regulation Of Heart Contraction	Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Tube Development Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Negative Regulation Of Signaling Regulation Of Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Macromolecule Biosynthetic Process Tissue Development Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cardiac Right Ventricle Formation Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Morphogenesis Negative Regulation Of DNA Binding Embryonic Morphogenesis System Development
Tagcloud ?		absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak	bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw
Tagcloud (Difference) ?		absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak	bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw
Tagcloud (Intersection) ?