MAGI1 and IL6R

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		MAGI1	IL6R
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	interleukin 6 receptor
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation
Drugs
Diseases
GWAS		PR interval ( 23534349)	Asthma ( 21907864) C-reactive protein ( 19567438 18439548 21300955) Fibrinogen ( 20031577) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	10 interactors: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SRC STAT3 WWP1 WWP2
Entrez ID		9223	3570
HPRD ID		04020	01000
Ensembl ID		ENSG00000151276	ENSG00000160712
Uniprot IDs		Q96QZ7	A0N0L5 P08887
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU	1N26 1N2Q 1P9M 2ARW
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Interleukin-6-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein Phosphorylation Viral Process Bone Remodeling Positive Regulation Of JAK-STAT Cascade Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of JAK-STAT Cascade Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ossification Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Tissue Remodeling Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Modification Process Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Temperature Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Acute Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Regulation Of Ossification Cellular Response To Cytokine Stimulus Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Bone Resorption Cell Differentiation
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il21 intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il21 intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper
Tagcloud (Intersection) ?