MAGI1 and SYNPO

Number of citations of the paper that reports this interaction (PMID 12042308)
23

Data Source:
HPRD (in vivo, in vitro)

		MAGI1	SYNPO
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	synaptopodin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Stress Fiber Cytoplasm Tight Junction Postsynaptic Density Actin Cytoskeleton Dendritic Spine Perikaryon Postsynaptic Membrane
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Actin Binding Protein Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly
Pathways
Drugs
Diseases
GWAS		PR interval ( 23534349)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	6 interactors: MAGI1 NCK1 NCK2 NONO YWHAG YWHAZ
Entrez ID		9223	11346
HPRD ID		04020	12179
Ensembl ID		ENSG00000151276	ENSG00000171992
Uniprot IDs		Q96QZ7	Q8N3V7
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Peptidyl-serine Phosphorylation Regulation Of Signal Transduction Signal Complex Assembly Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Organelle Organization Lamellipodium Assembly Regulation Of Protein Phosphorylation Lamellipodium Organization Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cell Death Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Protein Polymerization Cell Activation Cellular Response To Stimulus Positive Regulation Of Translation In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Cellular Component Assembly Regulation Of T Cell Proliferation Regulation Of Protein Kinase Activity Positive Regulation Of Transport
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	appearances barely cxxc5 deg degs egfl7 exclusions exon fhl1 foxm1 gains hub inclusions ingenuity ipa maz multilateral ndrg2 pah phh plk1 rcan1 reads seq signatures suddenly tmpo transcriptomic ttll1
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	appearances barely cxxc5 deg degs egfl7 exclusions exon fhl1 foxm1 gains hub inclusions ingenuity ipa maz multilateral ndrg2 pah phh plk1 rcan1 reads seq signatures suddenly tmpo transcriptomic ttll1
Tagcloud (Intersection) ?