FATE1 and NRG4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FATE1	NRG4
Gene Name		fetal and adult testis expressed 1	neuregulin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Receptor Binding Growth Factor Activity
	Biological Process		Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Organ Development
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Red blood cell traits ( 23222517) Urate levels ( 23263486)
Protein-Protein Interactions		49 interactors: AGTRAP AQP9 BCL2L2 BIK BNIP2 BNIP3 BNIP3L BSND BTN2A2 CCDC155 CCDC70 CD302 CD79A CSF2RA DCTN5 EMD GPR25 INPP5K KCNS2 LNPEP MARCH2 MARCH5 MR1 NDUFB11 NRG4 NRSN1 PIN4 PRRG2 RNF183 RPRM SEC22A SEC22C SEC23B SLC38A1 SLC7A1 SNAP47 SYNDIG1 SYNE4 SYNGR1 SYNPR TBP TIMMDC1 TM4SF4 TMEM74 TRAF2 TRAF3IP3 USHBP1 USP20 YIPF4	2 interactors: ERBB4 FATE1
Entrez ID		89885	145957
HPRD ID		02346	14871
Ensembl ID		ENSG00000147378
Uniprot IDs		Q969F0	Q8WWG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Protein Catabolic Process Membrane Organization Vesicle Fusion With Golgi Apparatus Vesicle Fusion Positive Regulation Of Mitochondrial Fission Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Mitochondrial Changes Organelle Fusion Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrion Organization ER To Golgi Vesicle-mediated Transport Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Transport Positive Regulation Of Release Of Cytochrome C From Mitochondria Membrane Fusion Establishment Of Localization In Cell Regulation Of Mitochondrial Membrane Permeability Chromosome Localization To Nuclear Envelope Involved In Synapsis Positive Regulation Of Renal Water Transport Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Cellular Localization Regulation Of Membrane Permeability Protein Autoubiquitination	Cardiac Muscle Tissue Regeneration Central Nervous System Morphogenesis Positive Regulation Of STAT Protein Import Into Nucleus Mitochondrial Fragmentation Involved In Apoptotic Process Olfactory Bulb Interneuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Mammary Gland Epithelial Cell Differentiation Mitochondrial Fission Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Heart Growth Olfactory Bulb Development Olfactory Lobe Development Mammary Gland Alveolus Development Mammary Gland Lobule Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Organ Growth Neural Crest Cell Migration Regulation Of Phosphatidylinositol 3-kinase Activity Tissue Regeneration Lactation Regulation Of Heart Growth Regulation Of Lipid Kinase Activity Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of JAK-STAT Cascade Forebrain Neuron Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Neural Crest Cell Development Apoptotic Mitochondrial Changes Forebrain Generation Of Neurons Neural Crest Cell Differentiation Embryonic Pattern Specification Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Mammary Gland Epithelium Development Regulation Of Organ Growth Body Fluid Secretion Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Mesenchymal Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Striated Muscle Tissue Development Mesenchymal Cell Differentiation Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?			activating adjacent alternatively deaths downregulated downregulation egfr epidermal gastric her2 her3 her4 immunohistochemistry interesting interestingly isoforms ligands matched oncogenes paired played qpcr quantified spliced splicing tissue unchanged undergoing upregulated
Tagcloud (Difference) ?			activating adjacent alternatively deaths downregulated downregulation egfr epidermal gastric her2 her3 her4 immunohistochemistry interesting interestingly isoforms ligands matched oncogenes paired played qpcr quantified spliced splicing tissue unchanged undergoing upregulated
Tagcloud (Intersection) ?