TRIM24 and TAF1C

Number of citations of the paper that reports this interaction (PMID 12393749)
25

Data Source:
HPRD (in vitro)

		TRIM24	TAF1C
Gene Name		tripartite motif containing 24	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Cytosol	Nucleoplasm
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ligand-dependent Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Sequence-specific DNA Binding Lysine-acetylated Histone Binding	DNA Binding Protein Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression SIRT1 negatively regulates rRNA Expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS		Quantitative traits ( 19197348)	Autism ( 22843504) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		47 interactors: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FOSL1 GTF2E1 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HNF4A HSPA1A NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2U VDR ZNF10	14 interactors: H2AFX POLR1E RRN3 SMN1 TAF1A TAF1B TAF1D TBP TK1 TP53 TRIM24 TTR UBTF UFD1L
Entrez ID		8805	9013
HPRD ID		04556	05364
Ensembl ID		ENSG00000122779	ENSG00000103168
Uniprot IDs		O15164	B3KUE8 Q15572
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing At RDNA Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Gene Expression Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication-dependent Nucleosome Assembly Chromatin Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Methylation On Cytosine Steroid Hormone Mediated Signaling Pathway Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Silencing Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA Methylation Gene Silencing Regulation Of Gene Expression, Epigenetic Cellular Response To Steroid Hormone Stimulus Transcription, DNA-templated DNA Modification RNA Biosynthetic Process Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Metabolic Process RNA Metabolic Process Protein-DNA Complex Assembly Nucleosome Assembly Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization Cellular Response To Lipid Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly	Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Regulation Of Gene Expression, Epigenetic Chromatin Silencing Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression RRNA Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Gene Silencing Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Transcription From RNA Polymerase III Promoter Cellular Macromolecular Complex Assembly Cellular Component Assembly Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Fetal Process Involved In Parturition Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromitophagy Skeletal Muscle Cell Proliferation
Tagcloud ?		advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable	analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1a taf1b tata tbp tumourigenesis ubf
Tagcloud (Difference) ?		advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable	analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1a taf1b tata tbp tumourigenesis ubf
Tagcloud (Intersection) ?