TRIM24 and CBX5

Number of citations of the paper that reports this interaction (PMID 10562550)
108

Data Source:
HPRD (in vitro)

		TRIM24	CBX5
Gene Name		tripartite motif containing 24	chromobox homolog 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Cytosol	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ligand-dependent Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Sequence-specific DNA Binding Lysine-acetylated Histone Binding	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Quantitative traits ( 19197348)	Mean platelet volume ( 22139419)
Protein-Protein Interactions		47 interactors: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FOSL1 GTF2E1 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HNF4A HSPA1A NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2U VDR ZNF10	50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1
Entrez ID		8805	23468
HPRD ID		04556	05131
Ensembl ID		ENSG00000122779	ENSG00000094916
Uniprot IDs		O15164	P45973
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37	3FDT 3I3C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing At RDNA Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Gene Expression Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication-dependent Nucleosome Assembly Chromatin Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Methylation On Cytosine Steroid Hormone Mediated Signaling Pathway Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Silencing Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA Methylation Gene Silencing Regulation Of Gene Expression, Epigenetic Cellular Response To Steroid Hormone Stimulus Transcription, DNA-templated DNA Modification RNA Biosynthetic Process Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Metabolic Process RNA Metabolic Process Protein-DNA Complex Assembly Nucleosome Assembly Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization Cellular Response To Lipid Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly	Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification
Tagcloud ?		advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable	1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Difference) ?		advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable	1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Intersection) ?