EED and EZH1

Number of citations of the paper that reports this interaction (PMID 9584197)
37

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		EED	EZH1
Gene Name		embryonic ectoderm development	enhancer of zeste 1 polycomb repressive complex 2 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus	Nucleoplasm ESC/E(Z) Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding	Chromatin Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anatomical Structure Morphogenesis Histone H3-K27 Methylation
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	3 interactors: E2F6 EED ZMYND11
Entrez ID		8726	2145
HPRD ID		09343	03397
Ensembl ID		ENSG00000074266	ENSG00000108799
Uniprot IDs		E9PJK2 O75530	Q92800
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Chromatin Modification RNA Metabolic Process Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of JNK Cascade Genetic Imprinting Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Chromosome Organization Regulation Of Transcription, DNA-templated Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription, Elongation Regulation Of Histone Methylation Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone Modification Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cell Cycle Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Histone Methylation Regulation Of Histone Modification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Regulation Of JNK Cascade
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	coimmunoprecipitation combs continuously delimited demonstrates directed discuss disrupt drosophila earlier embryo embryogenesis enhancer esc evolution extra heed homologs hybrid impair maintain partnership pc polycomb repressors silencing zeste
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally ectoderm ezh2 fragment gal4 homolog hypomorphic lethal mammalian repeats represses repressor silenced t1031a t1040c wd40 yeast	coimmunoprecipitation combs continuously delimited demonstrates directed discuss disrupt earlier embryo embryogenesis enhancer evolution extra heed homologs impair maintain partnership pc repressors silencing
Tagcloud (Intersection) ?		drosophila esc hybrid polycomb zeste