IRS2 and ATP2A1

Number of citations of the paper that reports this interaction (PMID 9295312)
7

Data Source:
HPRD (in vivo, in vitro)

		IRS2	ATP2A1
Gene Name		insulin receptor substrate 2	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane H Zone I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lipid Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Glucose Stimulus	Calcium Ion Transport Regulation Of Striated Muscle Contraction Blood Coagulation Metabolic Process Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Ion transport by P-type ATPases Ion channel transport Pre-NOTCH Processing in Golgi Platelet homeostasis Reduction of cytosolic Ca++ levels Signaling by NOTCH Pre-NOTCH Expression and Processing Platelet calcium homeostasis
Drugs
Diseases
GWAS			Body mass index ( 19079260) Weight ( 19079260)
Protein-Protein Interactions		38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ	4 interactors: IRS1 IRS2 PLN SLN
Entrez ID		8660	487
HPRD ID		02878	00157
Ensembl ID		ENSG00000185950	ENSG00000196296
Uniprot IDs		Q9P084 Q9Y4H2	B3KY17 O14983 Q7Z675
PDB IDs		3FQW 3FQX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Organic Substance Cellular Response To Peptide Response To Peptide Hormone Response To Peptide Response To Organonitrogen Compound Response To Organic Substance Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Response To Hormone Cellular Response To Insulin Stimulus Cell Surface Receptor Signaling Pathway Response To Insulin Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Phosphorylation Innate Immune Response Defense Response Regulation Of Protein Kinase Activity Response To Stress Regulation Of Signal Transduction Regulation Of Immune System Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Response To Cytokine Immune System Process Cellular Response To Cytokine Stimulus Regulation Of Protein Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding Regulation Of Intracellular Transport ERBB Signaling Pathway Locomotion	Negative Regulation Of Calcium Ion Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Transport Negative Regulation Of Calcium Ion Import Negative Regulation Of Ion Transport Regulation Of Relaxation Of Muscle Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Calcium Ion Import Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Lipid Catabolic Process Response To Insulin Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Glucose Metabolic Process Regulation Of Glycogen Metabolic Process Response To Growth Hormone Negative Regulation Of Transporter Activity Regulation Of ATPase Activity Negative Regulation Of Calcium Ion Transport Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Import Regulation Of Ion Transmembrane Transport Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Transport Response To Peptide Hormone JAK-STAT Cascade Regulation Of Lipid Catabolic Process Response To Peptide Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Glucose Import Positive Regulation Of Stem Cell Proliferation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Ion Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Cellular Component Movement Regulation Of Glucose Transport Negative Regulation Of Binding Regulation Of Catalytic Activity Regulation Of Glucose Metabolic Process Regulation Of Stem Cell Proliferation
Tagcloud ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Difference) ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Intersection) ?