IRS2 and MPL

Number of citations of the paper that reports this interaction (PMID 11054408)
21

Data Source:
HPRD (in vivo)

		IRS2	MPL
Gene Name		insulin receptor substrate 2	MPL proto-oncogene, thrombopoietin receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signal Transducer Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lipid Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Glucose Stimulus	Cell Surface Receptor Signaling Pathway Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Platelet Activation Regulation Of Chemokine Production Homeostasis Of Number Of Cells
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ	9 interactors: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		8660	4352
HPRD ID		02878	01161
Ensembl ID		ENSG00000185950	ENSG00000117400
Uniprot IDs		Q9P084 Q9Y4H2	P40238
PDB IDs		3FQW 3FQX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Organic Substance Cellular Response To Peptide Response To Peptide Hormone Response To Peptide Response To Organonitrogen Compound Response To Organic Substance Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Response To Hormone Cellular Response To Insulin Stimulus Cell Surface Receptor Signaling Pathway Response To Insulin Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Phosphorylation Innate Immune Response Defense Response Regulation Of Protein Kinase Activity Response To Stress Regulation Of Signal Transduction Regulation Of Immune System Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Response To Cytokine Immune System Process Cellular Response To Cytokine Stimulus Regulation Of Protein Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding Regulation Of Intracellular Transport ERBB Signaling Pathway Locomotion	Cellular Response To Peptide Hormone Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Growth Hormone Response To Peptide JAK-STAT Cascade Cellular Response To Hormone Stimulus Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Response To Organonitrogen Compound Positive Regulation Of Hormone Secretion Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Interferon-gamma-mediated Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Cellular Response To Interferon-gamma Regulation Of Protein Phosphorylation Insulin Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Interferon-gamma Negative Regulation Of Lipid Transport Immune System Process Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Cytokine Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Signal Transduction Wound Healing Regulation Of Insulin Secretion
Tagcloud ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic hoxb4 identify impact implicated loci major mapping numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Difference) ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic hoxb4 identify impact implicated loci major mapping numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Intersection) ?