CUL4B and AHR

Number of citations of the paper that reports this interaction (PMID 17392787)
92

Data Source:
HPRD (in vivo)

		CUL4B	AHR
Gene Name		cullin 4B	aryl hydrocarbon receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex
	Molecular Function	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding E-box Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Histone H2A Monoubiquitination Positive Regulation Of Protein Catabolic Process UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Xenobiotic Metabolic Process Apoptotic Process Cell Cycle Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Prostate Gland Development Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Caffeine consumption ( 21490707) Coffee consumption ( 21357676) Metabolic traits ( 21886157)
Protein-Protein Interactions		22 interactors: AHR APP AR CAND1 COMMD1 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 DTL ESR1 KPNA2 KPNA4 KPNB1 NEDD8 RBX1 RNF7 SALL2 SIN3A UBC	34 interactors: AIP AR ARNT ARNTL BRCA1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 SRC STUB1 TAF4 TAF6 TAF7 TAF9 TBP XPO1
Entrez ID		8450	196
HPRD ID		02251	02596
Ensembl ID		ENSG00000158290	ENSG00000106546
Uniprot IDs		Q13620	P35869
PDB IDs		2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Neddylation Protein Ubiquitination Intracellular Receptor Signaling Pathway NLS-bearing Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To UV Cellular Macromolecule Catabolic Process Response To Light Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly UV-damage Excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Radiation Regulation Of Cell Cycle Phase Transition Histone H2A Monoubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Modification-dependent Protein Catabolic Process Cellular Response To Stimulus Histone H2A Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Initiation Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Organic Substance Rhythmic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Import Into Nucleus Histone Monoubiquitination DNA Repair Nuclear Import Regulation Of DNA-templated Transcription, Initiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Copper Ion Homeostasis Regulation Of Apoptotic Process	Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Viral Process Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Cellular Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Signal Transduction
Tagcloud ?		absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination	12f actions aryl biologically constant dioxin dissociation eadie elicited equilibrium exert exerts half hofstee hydrocarbon kd keratinocytes lost maximal modulating opposing pmol ra rars scc tcdbf tcdd tetrachlorodibenzo trans
Tagcloud (Difference) ?		absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination	12f actions aryl biologically constant dioxin dissociation eadie elicited equilibrium exert exerts half hofstee hydrocarbon kd keratinocytes lost maximal modulating opposing pmol ra rars scc tcdbf tcdd tetrachlorodibenzo trans
Tagcloud (Intersection) ?