AHR and ARNTL

Number of citations of the paper that reports this interaction (PMID 9079689)
69

Data Source:
HPRD (in vivo, two hybrid)

		AHR	ARNTL
Gene Name		aryl hydrocarbon receptor	aryl hydrocarbon receptor nuclear translocator-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex	Nucleus Transcription Factor Complex PML Body Chromatoid Body
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding E-box Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Aryl Hydrocarbon Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Xenobiotic Metabolic Process Apoptotic Process Cell Cycle Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Prostate Gland Development Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter	Protein Import Into Nucleus, Translocation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Coffee consumption ( 21357676) Metabolic traits ( 21886157)	Menarche (age at onset) ( 21102462) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Schizophrenia ( 23358160)
Protein-Protein Interactions		34 interactors: AIP AR ARNT ARNTL BRCA1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 SRC STUB1 TAF4 TAF6 TAF7 TAF9 TBP XPO1	20 interactors: AHR BHLHE40 CLOCK CRY1 CSNK1E EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RXRA SIRT1 SUMO2 SUMO3 UBE2I
Entrez ID		196	406
HPRD ID		02596	03973
Ensembl ID		ENSG00000106546	ENSG00000133794
Uniprot IDs		P35869	O00327
PDB IDs			4H10
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Viral Process Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Cellular Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Signal Transduction	Rhythmic Process Circadian Regulation Of Gene Expression Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peptidyl-lysine Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Peptidyl-amino Acid Modification Signal Transduction Protein Sumoylation Regulation Of Cellular Process Regulation Of Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Photoperiodism Cellular Response To Hypoxia Response To Abiotic Stimulus
Tagcloud ?		12f actions aryl biologically constant dioxin dissociation eadie elicited equilibrium exert exerts half hofstee hydrocarbon kd keratinocytes lost maximal modulating opposing pmol ra rars scc tcdbf tcdd tetrachlorodibenzo trans	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Difference) ?		12f actions aryl biologically constant dioxin dissociation eadie elicited equilibrium exert exerts half hofstee hydrocarbon kd keratinocytes lost maximal modulating opposing pmol ra rars scc tcdbf tcdd tetrachlorodibenzo trans	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Intersection) ?