CCM2 and POT1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		CCM2	POT1
Gene Name		cerebral cavernous malformation 2	protection of telomeres 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Protein Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding
	Biological Process	Vasculogenesis In Utero Embryonic Development Endothelial Cell Development Integrin-mediated Signaling Pathway Multicellular Organism Growth Cell-cell Junction Organization Inner Ear Development Venous Blood Vessel Morphogenesis Stress-activated MAPK Cascade Pericardium Development Blood Vessel Endothelial Cell Differentiation Endothelial Tube Morphogenesis	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: POT1 SMURF1 SRPK2	166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		83605	25913
HPRD ID		09719	07572
Ensembl ID		ENSG00000136280	ENSG00000128513
Uniprot IDs		Q9BSQ5	A8MTK3 Q5MJ33 Q9NUX5
PDB IDs		4FQN	1XJV 3KJO 3KJP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Strand Elongation Nuclear Speck Organization Telomere Formation Via Telomerase Positive Regulation Of Helicase Activity Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Protein Localization To Cell Surface Positive Regulation Of DNA Biosynthetic Process Receptor Catabolic Process Positive Regulation Of Viral Genome Replication RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Ectoderm Development Telomere Maintenance Via Telomere Lengthening Protein Export From Nucleus Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Viral Genome Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of DNA Replication Telomere Maintenance Regulation Of Viral Genome Replication Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Viral Process Positive Regulation Of Neuron Death BMP Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Negative Regulation Of Ossification Receptor Metabolic Process Regulation Of BMP Signaling Pathway Regulation Of MRNA Processing Negative Regulation Of Chromosome Organization	Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process
Tagcloud ?			0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?			0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Intersection) ?