HIST2H2BE and SIRT7

Number of citations of the paper that reports this interaction (PMID 16618798)
81

Data Source:
BioGRID (pull down)

		HIST2H2BE	SIRT7
Gene Name		histone cluster 2, H2be	sirtuin 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleolus Nucleolus Organizer Region Cytoplasm
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Chromatin Binding Protein Binding Metal Ion Binding NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription On Exit From Mitosis RRNA Transcription Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1	6 interactors: APP HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MAGED1
Entrez ID		8349	51547
HPRD ID		03494	12094
Ensembl ID		ENSG00000184678	ENSG00000187531
Uniprot IDs		Q16778	Q9NRC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly Chromatin Assembly DNA Methylation On Cytosine Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Silencing At RDNA Protein-DNA Complex Assembly DNA Packaging Chromatin Silencing DNA Conformation Change DNA Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Cellular Macromolecular Complex Assembly Synaptic Growth At Neuromuscular Junction Chromatin Organization Cellular Component Assembly Collateral Sprouting In Absence Of Injury Histone H4-K20 Demethylation Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Protein Complex Assembly Axon Choice Point Recognition Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Methylation Innate Immune Response In Mucosa Blood Coagulation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Cellular Copper Ion Homeostasis Hemostasis Regulation Of Megakaryocyte Differentiation Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle CENP-A Containing Nucleosome Assembly
Tagcloud ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	advanced aimed altered biomarkers carcinoma circulating family head healthy hnscc individuals leukocytes markers neck pb peripheral possibility postoperative profiles prognostic recovery regulated sirt1 sirt3 sirt6 squamous stage surgery
Tagcloud (Difference) ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	advanced aimed altered biomarkers carcinoma circulating family head healthy hnscc individuals leukocytes markers neck pb peripheral possibility postoperative profiles prognostic recovery regulated sirt1 sirt3 sirt6 squamous stage surgery
Tagcloud (Intersection) ?