HIST2H2BE and NCL

Number of citations of the paper that reports this interaction (PMID 16601700)
60

Data Source:
BioGRID (pull down)

		HIST2H2BE	NCL
Gene Name		histone cluster 2, H2be	nucleolin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cell Cortex Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Nucleotide Binding RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Angiogenesis Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 23728934) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1	48 interactors: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CSNK2A1 CSNK2A2 ERG ETS1 FMR1 GRB2 GZF1 GZMA H2AFX HIST1H1C HIST2H2AC HIST2H2BE HIST3H3 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PTGS1 S100A11 SREK1 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689
Entrez ID		8349	4691
HPRD ID		03494	01245
Ensembl ID		ENSG00000184678
Uniprot IDs		Q16778	B3KM80 P19338 Q9BQ02
PDB IDs			2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	Chromosome Organization DNA Conformation Change Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Chromatin Organization Response To Stimulus Nucleobase-containing Compound Metabolic Process Cellular Response To Stress DNA Packaging Cellular Response To Stimulus Developmental Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Regulation Of Apoptotic Process Chromatin Assembly Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Regulation Of Cell Death Chromatin Assembly Or Disassembly Response To Stress Mitotic Cell Cycle Checkpoint Regulation Of Cell Proliferation DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Aging Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Aging Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process RNA Biosynthetic Process Cellular Senescence Double-strand Break Repair Protein Complex Assembly DNA Damage Checkpoint Cell Cycle Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle Process
Tagcloud ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition restored reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Difference) ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restoring serve sgc susceptibility transfection tumorigenesis	affinity capping corresponding deletion eif end eucaryotic fold free germ hairpin initiation interference leader loop mrna noncoding ovalbumin rabbit rate recognition reticulocyte secondary sequence structure systems translation wheat
Tagcloud (Intersection) ?		restored