NCOA3 and CDKN3

Number of citations of the paper that reports this interaction (PMID 21577200)
17

Data Source:
BioGRID (two hybrid)

		NCOA3	CDKN3
Gene Name		nuclear receptor coactivator 3	cyclin-dependent kinase inhibitor 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Transcription, DNA-templated Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Multicellular Organism Growth Receptor Transactivation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Vagina Development Labyrinthine Layer Morphogenesis Mammary Gland Branching Involved In Thelarche Regulation Of RNA Biosynthetic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Response to treatment for acute lymphoblastic leukemia ( 19176441)	Dental caries ( 23259602) Working memory ( 21107309)
Protein-Protein Interactions		77 interactors: ABL1 ANKRD11 AR ARNT2 ATAD2 BMP6 BMP7 BRCA1 BRE CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B HIST3H3 HIST4H4 IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	7 interactors: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3
Entrez ID		8202	1033
HPRD ID		03570	00450
Ensembl ID		ENSG00000124151	ENSG00000100526
Uniprot IDs		Q0IIN7 Q59EE8 Q9Y6Q9	F5H232 Q16667
PDB IDs		1KBH 3L3X 3L3Z	1FPZ 1FQ1
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Steroid Hormone Response To Lipid Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Regulation Of Gene Expression Response To Hormone Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of RNA Biosynthetic Process Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Communication Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Regulation Of Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Organelle Organization DNA Replication Histone Phosphorylation Cell Cycle Process Centrosome Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Histone Modification Positive Regulation Of DNA Replication Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Organ Regeneration Response To Inorganic Substance Regulation Of Ubiquitin-protein Transferase Activity Pronuclear Fusion Cell Cycle Mitotic DNA Damage Checkpoint Centrosome Organization Mitotic DNA Integrity Checkpoint Cellular Response To Reactive Oxygen Species Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Placenta Development Positive Regulation Of Gene Expression Chromatin Modification Regulation Of DNA Replication G0 To G1 Transition Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Inorganic Substance Cellular Protein Modification Process Positive Regulation Of DNA Metabolic Process DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Checkpoint Response To Vitamin B2 Positive Regulation Of DNA-dependent DNA Replication Initiation Cellular Macromolecule Biosynthetic Process Placenta Development Response To Reactive Oxygen Species Receptor Transactivation Macromolecule Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination
Tagcloud ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations	aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression
Tagcloud (Difference) ?		acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations	aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression
Tagcloud (Intersection) ?