CDKN3 and CDK3

Number of citations of the paper that reports this interaction (PMID 8242750)
471

Data Source:
HPRD (two hybrid, in vivo)

		CDKN3	CDK3
Gene Name		cyclin-dependent kinase inhibitor 3	cyclin-dependent kinase 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Cell Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS		Dental caries ( 23259602) Working memory ( 21107309)
Protein-Protein Interactions		7 interactors: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3	18 interactors: APP CABLES1 CABLES2 CCNA2 CCNC CCNE1 CCNE2 CDC37 CDKN1A CDKN1B CDKN3 E2F1 E2F2 E2F3 KIR3DL1 NEDD4L PPARA RB1
Entrez ID		1033	1018
HPRD ID		00450	00446
Ensembl ID		ENSG00000100526	ENSG00000250506
Uniprot IDs		F5H232 Q16667	Q00526
PDB IDs		1FPZ 1FQ1	1LFN
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Regulation Of Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Organelle Organization DNA Replication Histone Phosphorylation Cell Cycle Process Centrosome Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Histone Modification Positive Regulation Of DNA Replication Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Organ Regeneration Response To Inorganic Substance Regulation Of Ubiquitin-protein Transferase Activity Pronuclear Fusion Cell Cycle Mitotic DNA Damage Checkpoint Centrosome Organization Mitotic DNA Integrity Checkpoint Cellular Response To Reactive Oxygen Species Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Placenta Development Positive Regulation Of Gene Expression Chromatin Modification Regulation Of DNA Replication G0 To G1 Transition Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Inorganic Substance Cellular Protein Modification Process Positive Regulation Of DNA Metabolic Process DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Checkpoint Response To Vitamin B2 Positive Regulation Of DNA-dependent DNA Replication Initiation Cellular Macromolecule Biosynthetic Process Placenta Development Response To Reactive Oxygen Species Receptor Transactivation Macromolecule Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination	Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Checkpoint Cell Division Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Mitotic Cell Cycle DNA-templated Transcription, Initiation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Lens Fiber Cell Apoptotic Process Notch Signaling Pathway Regulation Of Gene Expression Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Signaling Negative Regulation Of Mitotic Cell Cycle
Tagcloud ?		aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression	3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel
Tagcloud (Difference) ?		aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression	3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel
Tagcloud (Intersection) ?