TTN and TCAP

Number of citations of the paper that reports this interaction (PMID 15802564)
99

Data Source:
BioGRID (pull down, two hybrid, enzymatic study)
HPRD (in vivo, in vitro, two hybrid)

		TTN	TCAP
Gene Name		titin	titin-cap
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome	Cytosol Z Disc I Band
	Molecular Function	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity	Protein Binding Structural Constituent Of Muscle Protein Binding, Bridging Titin Binding BMP Binding Ion Channel Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Protein Complex Assembly Adult Heart Development Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Cardiac Muscle Fiber Development Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Striated Muscle Contraction
Drugs
Diseases
GWAS		Breast size ( 22747683) QT interval ( 20031603)
Protein-Protein Interactions		29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2	14 interactors: ANKRD2 ATXN1 FAS FYN MDM2 MSTN MYOZ1 MYOZ3 PDPK1 RELA SIVA1 TRIM55 TRIM63 TTN
Entrez ID		7273	8557
HPRD ID		01787	05133
Ensembl ID		ENSG00000155657
Uniprot IDs		Q7Z3B7 Q8WZ42	A2TDC0 O15273
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3	1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation	Response To Abiotic Stimulus Response To Hormone Cellular Response To Hormone Stimulus Response To Steroid Hormone Skeletal Muscle Atrophy Response To Mechanical Stimulus Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Atrophy Activation-induced Cell Death Of T Cells Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Death Muscle Atrophy Cellular Response To Growth Factor Stimulus Muscle System Process Response To Growth Factor Skeletal Muscle Adaptation Fc Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Substance Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Response To Stimulus T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Apoptotic Process Organ Development Cellular Response To Organic Cyclic Compound Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling Response To Lipid Regulation Of Protein Metabolic Process Cellular Response To Lipid Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Negative Regulation Of Apoptotic Process Signaling Response To Glucocorticoid Negative Regulation Of Programmed Cell Death Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Communication Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance
Tagcloud ?		amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl	allegedly catalysis conformationally coordinating crd dichotomy e147 inactivity invertebrate m34 mechanosensing murf1 murf2 myofibril myofibrillogenesis myofilament pseudokinase pseudokinases releases sarcomeric sterically stretch striated titin tk transfers translates trophicity unfolding
Tagcloud (Difference) ?		amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl	allegedly catalysis conformationally coordinating crd dichotomy e147 inactivity invertebrate m34 mechanosensing murf1 murf2 myofibril myofibrillogenesis myofilament pseudokinase pseudokinases releases sarcomeric sterically stretch striated titin tk transfers translates trophicity unfolding
Tagcloud (Intersection) ?