TTN and CAPN3

Number of citations of the paper that reports this interaction (PMID 8537379)
46

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TTN	CAPN3
Gene Name		titin	calpain 3, (p94)
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome	Intracellular Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein Complex
	Molecular Function	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Protein Complex Scaffold Ligase Regulator Activity
	Biological Process	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Autolysis Protein Complex Assembly Proteolysis Apoptotic Process Signal Transduction Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Myofibril Assembly Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis
Pathways		Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Breast size ( 22747683) QT interval ( 20031603)	Triglycerides ( 20686565)
Protein-Protein Interactions		29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2	7 interactors: DYSF FLNC NECAB2 OSGIN1 TTN WDYHV1 YWHAQ
Entrez ID		7273	825
HPRD ID		01787	00255
Ensembl ID		ENSG00000155657	ENSG00000092529
Uniprot IDs		Q7Z3B7 Q8WZ42	C6EVS3 C6EVS4 P20807
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3	1Y9V
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation	Muscle Fiber Development Striated Muscle Cell Development Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development Directional Locomotion Myosin Filament Assembly Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Plasma Membrane Repair Muscle Cell Differentiation
Tagcloud ?		amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl	accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst
Tagcloud (Difference) ?		amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl	accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst
Tagcloud (Intersection) ?