HLTF and UBE2V2

Number of citations of the paper that reports this interaction (PMID 18316726)
37

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		HLTF	UBE2V2
Gene Name		helicase-like transcription factor	ubiquitin-conjugating enzyme E2 variant 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane	Nucleus Cytoplasm UBC13-MMS2 Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity ATPase Activity Poly(A) RNA Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Postreplication Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Cell Proliferation Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of Synapse Assembly Protein K63-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CDK9 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2N UBE2V2 UBE2Z WBP4	22 interactors: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 OTUB1 RNF144A RNF2 RNF8 SHPRH SIAH1 SUV39H2 TRAF2 TRIM5 UBC UBE2N XIAP ZNRF1
Entrez ID		6596	7336
HPRD ID		04461	04300
Ensembl ID		ENSG00000071794
Uniprot IDs		Q05BZ6 Q14527	A0M8W4 G3V113 Q15819
PDB IDs		2L1I 4HRE 4HRH	1J74 1J7D 1ZGU 3VON 4EPO
Enriched GO Terms of Interacting Partners?		Postreplication Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Repair Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair Cellular Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Protein Ubiquitination Embryonic Process Involved In Female Pregnancy DNA Metabolic Process Protein Modification By Small Protein Conjugation Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Megakaryocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Definitive Hemopoiesis Positive Regulation Of DNA Metabolic Process Trophectodermal Cell Differentiation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Protein K63-linked Ubiquitination Response To Transforming Growth Factor Beta DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Repair Histone Ubiquitination Positive Regulation Of Metabolic Process Viral Process Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA-templated Transcription, Initiation Embryonic Eye Morphogenesis Female Pregnancy Positive Regulation Of Viral Transcription Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Macromolecule Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of DNA Repair Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Histone Ubiquitination Regulation Of Histone Ubiquitination Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Metabolic Process Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Immune System Process DNA Repair Protein Catabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		672e aside attenuates bambi bmp5 brains cflar cohesion condensation disrupts encephalomalacia exons metacore null participates postpartum rad21 rad5 scc1 scgb3a1 seq smad7 smc2 snapshot tnfrsf6 transcriptome triggering unidentified wnt10b	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Difference) ?		672e aside attenuates bambi bmp5 brains cflar cohesion condensation disrupts encephalomalacia exons metacore null participates postpartum rad21 rad5 scc1 scgb3a1 seq smad7 smc2 snapshot tnfrsf6 transcriptome triggering unidentified wnt10b	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Intersection) ?