HLTF and SP3

Number of citations of the paper that reports this interaction (PMID 10391891)
8

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HLTF	SP3
Gene Name		helicase-like transcription factor	Sp3 transcription factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane PML Body Transcriptional Repressor Complex
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity ATPase Activity Poly(A) RNA Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Postreplication Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CDK9 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2N UBE2V2 UBE2Z WBP4	19 interactors: E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF NKX3-1 PIAS1 RB1 RBBP4 SP1 STK19 SUMO1 TP53 UBE2I ZBTB7A
Entrez ID		6596	6670
HPRD ID		04461	03483
Ensembl ID		ENSG00000071794	ENSG00000172845
Uniprot IDs		Q05BZ6 Q14527	B7ZLN9 Q02447 Q59FX5 Q86TP0
PDB IDs		2L1I 4HRE 4HRH
Enriched GO Terms of Interacting Partners?		Postreplication Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Repair Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair Cellular Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Protein Ubiquitination Embryonic Process Involved In Female Pregnancy DNA Metabolic Process Protein Modification By Small Protein Conjugation Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Megakaryocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Definitive Hemopoiesis Positive Regulation Of DNA Metabolic Process Trophectodermal Cell Differentiation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Protein K63-linked Ubiquitination Response To Transforming Growth Factor Beta DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Repair Histone Ubiquitination Positive Regulation Of Metabolic Process Viral Process Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA-templated Transcription, Initiation Embryonic Eye Morphogenesis Female Pregnancy Positive Regulation Of Viral Transcription Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Macromolecule Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process	Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Rhythmic Process RNA Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Signaling Response To Organic Substance Biosynthetic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Chromatin Modification Regulation Of Cell Cycle Chromatin Remodeling Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Chromosome Organization Regulation Of Cell Proliferation Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		672e aside attenuates bambi bmp5 brains cflar cohesion condensation disrupts encephalomalacia exons metacore null participates postpartum rad21 rad5 scc1 scgb3a1 seq smad7 smc2 snapshot tnfrsf6 transcriptome triggering unidentified wnt10b
Tagcloud (Difference) ?		672e aside attenuates bambi bmp5 brains cflar cohesion condensation disrupts encephalomalacia exons metacore null participates postpartum rad21 rad5 scc1 scgb3a1 seq smad7 smc2 snapshot tnfrsf6 transcriptome triggering unidentified wnt10b
Tagcloud (Intersection) ?