SIAH1 and FZD9

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SIAH1	FZD9
Gene Name		siah E3 ubiquitin protein ligase 1	frizzled class receptor 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	G-protein Coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Protein Heterodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory B Cell Differentiation Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		Axon guidance Netrin-1 signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671	6 interactors: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A
Entrez ID		6477	8326
HPRD ID		03736	03460
Ensembl ID		ENSG00000196470	ENSG00000188763
Uniprot IDs		Q8IUQ4	O00144
PDB IDs		2A25 4I7B 4I7C 4I7D
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Apoptotic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Innate Immune Response Protein Ubiquitination Protein K48-linked Ubiquitination Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Defense Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune Response Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Immune System Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Cellular Response To Stress Cellular Response To Organic Substance Response To Cytokine Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Stimulus Regulation Of Chromosome Organization	Positive Regulation Of Receptor Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Axis Specification Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Anatomical Structure Morphogenesis Wnt Signaling Pathway Organ Morphogenesis Positive Regulation Of Embryonic Development Cell Fate Commitment Regulation Of Signal Transduction Neuron Differentiation Embryo Development Single Organism Reproductive Process Regulation Of Signaling Cerebellum Morphogenesis Developmental Induction Reproductive Process Embryonic Axis Specification Hindbrain Morphogenesis Cell Differentiation Positive Regulation Of Fibroblast Proliferation Pattern Specification Process Embryonic Organ Development Reproductive Structure Development Generation Of Neurons Reproductive System Development Neurogenesis Skeletal System Development Embryonic Pattern Specification Sensory Organ Development Lens Development In Camera-type Eye Regulation Of Fibroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter System Development Embryonic Morphogenesis Tissue Morphogenesis Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Wnt Signaling Pathway Involved In Wound Healing, Spreading Of Epidermal Cells Embryonic Placenta Development Cerebellum Development Regulation Of Embryonic Development Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Tube Development
Tagcloud ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	ascl2 c4b dab2ip dlk1 eya4 fabp3 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Difference) ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	ascl2 c4b dab2ip dlk1 eya4 fabp3 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Intersection) ?