SIAH1 and ZNF148

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SIAH1	ZNF148
Gene Name		siah E3 ubiquitin protein ligase 1	zinc finger protein 148
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Nucleoplasm Golgi Apparatus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Defense Response Gamete Generation Negative Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671	13 interactors: CCDC67 CEP70 EP300 GLRX3 GORASP2 KRT31 NUTM2F PTRF SIAH1 STAT3 TP53 TRIM10 UBC
Entrez ID		6477	7707
HPRD ID		03736	03540
Ensembl ID		ENSG00000196470	ENSG00000163848
Uniprot IDs		Q8IUQ4	Q9UQR1
PDB IDs		2A25 4I7B 4I7C 4I7D
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Apoptotic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Innate Immune Response Protein Ubiquitination Protein K48-linked Ubiquitination Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Defense Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune Response Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Immune System Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Cellular Response To Stress Cellular Response To Organic Substance Response To Cytokine Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Stimulus Regulation Of Chromosome Organization	Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic Cell Cycle Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Cell Cycle G2/M Transition Of Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Viral Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Regulation Of Protein Deacetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Neuron Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of DNA-templated Transcription In Response To Stress Signal Transduction Involved In DNA Damage Checkpoint Response To Hypoxia Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Rhythmic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Death Histone H2B Acetylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Type I Interferon Production Somitogenesis Signal Transduction In Response To DNA Damage Apoptotic Process Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Somite Development Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Programmed Cell Death
Tagcloud ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	11p15 19q13 1p36 20p11 3q21 7q11 7q21 alagille beckwith chromosomally deleted gli krab kruppel q22 shfd1 split straightforward wiedemann williams znf131 znf132 znf133 znf139 znf151 znfs
Tagcloud (Difference) ?		alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin	11p15 19q13 1p36 20p11 3q21 7q11 7q21 alagille beckwith chromosomally deleted gli krab kruppel q22 shfd1 split straightforward wiedemann williams znf131 znf132 znf133 znf139 znf151 znfs
Tagcloud (Intersection) ?