RPA2 and RAD1

Number of citations of the paper that reports this interaction (PMID 15897895)
42

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RPA2	RAD1
Gene Name		replication protein A2, 32kDa	RAD1 checkpoint DNA exonuclease
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding	Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cellular Response To Heat Regulation Of DNA Damage Checkpoint	DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ACP5 APP ATM CALCOCO2 CCNO CDC5L CDK1 CFB COPS6 CRMP1 EEF1A1 EIF4G2 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 KIAA1377 LRIF1 MCM2 MCM3 MCM4 MCM5 MED31 MEN1 ORC1 ORC2 ORC4 ORC5 PRKDC PRPF19 RAD1 RAD52 RAD9A RBM48 RFWD3 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA	15 interactors: COPS5 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 PARK2 POLB RAD17 RAD9B RPA1 RPA2
Entrez ID		6118	5810
HPRD ID		01566	04400
Ensembl ID		ENSG00000117748	ENSG00000113456
Uniprot IDs		P15927	O60671
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF	3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cell Cycle Process Cell Cycle DNA Replication Heterocycle Metabolic Process DNA Replication Initiation Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication DNA Repair G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To Stress Cell Cycle Checkpoint Response To Radiation Cellular Metabolic Process Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair Regulation Of Cell Cycle DNA Recombinase Assembly Response To Abiotic Stimulus DNA Recombination DNA Catabolic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Aromatic Compound Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction Involved In DNA Damage Checkpoint Metabolic Process	DNA Repair Cellular Response To Stress Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Recombination Cell Cycle Process Mismatch Repair DNA Replication Meiotic Mismatch Repair DNA Damage Checkpoint Cell Cycle Response To Stress Negative Regulation Of DNA Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Base-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Telomere Maintenance Via Semi-conservative Replication Nitrogen Compound Metabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination DNA-dependent DNA Replication Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Somatic Recombination Of Immunoglobulin Gene Segments Response To UV Somatic Diversification Of Immunoglobulins Maintenance Of DNA Repeat Elements Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division Cellular Metabolic Process DNA Recombinase Assembly Cellular Response To Stimulus Mitotic Cell Cycle Immunoglobulin Production Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Somatic Hypermutation Of Immunoglobulin Genes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?		53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide	abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad9 repeats repressor rhino tethering topbp1 uv
Tagcloud (Difference) ?		53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide	abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad9 repeats repressor rhino tethering topbp1 uv
Tagcloud (Intersection) ?