RPA2 and ORC4

Number of citations of the paper that reports this interaction (PMID 12614612)
16

Data Source:
BioGRID (two hybrid)

		RPA2	ORC4
Gene Name		replication protein A2, 32kDa	origin recognition complex, subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Actin Cytoskeleton
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cellular Response To Heat Regulation Of DNA Damage Checkpoint	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ACP5 APP ATM CALCOCO2 CCNO CDC5L CDK1 CFB COPS6 CRMP1 EEF1A1 EIF4G2 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 KIAA1377 LRIF1 MCM2 MCM3 MCM4 MCM5 MED31 MEN1 ORC1 ORC2 ORC4 ORC5 PRKDC PRPF19 RAD1 RAD52 RAD9A RBM48 RFWD3 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA	27 interactors: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 HIST3H3 HIST4H4 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RPA2 RRM2B TCF4
Entrez ID		6118	5000
HPRD ID		01566	09118
Ensembl ID		ENSG00000117748	ENSG00000115947
Uniprot IDs		P15927	A8K7H4 O43929 Q96B14
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cell Cycle Process Cell Cycle DNA Replication Heterocycle Metabolic Process DNA Replication Initiation Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication DNA Repair G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To Stress Cell Cycle Checkpoint Response To Radiation Cellular Metabolic Process Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair Regulation Of Cell Cycle DNA Recombinase Assembly Response To Abiotic Stimulus DNA Recombination DNA Catabolic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Aromatic Compound Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction Involved In DNA Damage Checkpoint Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication DNA Replication DNA Replication Initiation Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process Chromosome Organization DNA Unwinding Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process DNA Conformation Change DNA Duplex Unwinding DNA Geometric Change Biosynthetic Process Organelle Organization Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Regulation Of DNA Recombination Telomere Maintenance Regulation Of Mitotic Cell Cycle Phase Transition Cell Proliferation Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Cell Cycle Chromatin Assembly Cellular Process Cellular Macromolecular Complex Assembly Response To Epidermal Growth Factor Regulation Of Protein Export From Nucleus Chromatin Assembly Or Disassembly
Tagcloud ?		53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Difference) ?		53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Intersection) ?