ACTA2 and GC

Number of citations of the paper that reports this interaction (PMID 12119014)
10

Data Source:
HPRD (in vitro)

		ACTA2	GC
Gene Name		actin, alpha 2, smooth muscle, aorta	group-specific component (vitamin D binding protein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Smooth Muscle Contractile Fiber Protein Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytosol Lysosomal Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	ATP Binding Protein Kinase Binding	Actin Binding Vitamin D Binding Vitamin Transporter Activity Calcidiol Binding
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Vascular Smooth Muscle Contraction Glomerular Mesangial Cell Development	Steroid Metabolic Process Vitamin D Metabolic Process Small Molecule Metabolic Process Vitamin Transport
Pathways		Smooth Muscle Contraction	Metabolism of lipids and lipoproteins Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)	Metabolite levels ( 22916037) Non-alcoholic fatty liver disease histology (other) ( 23213074) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 22673963 20418485)
Protein-Protein Interactions		16 interactors: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SHBG SNTA1 TMSB4X YBX1	12 interactors: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 LRIF1 LRP2 PIK3R3 SERF2
Entrez ID		59	2638
HPRD ID		00031	00749
Ensembl ID		ENSG00000107796	ENSG00000145321
Uniprot IDs		D2JYH4 P62736	P02774
PDB IDs			1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation Regulation Of Actin Filament-based Process N-terminal Protein Amino Acid Acetylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Blood Coagulation N-terminal Protein Amino Acid Modification Hemostasis Negative Regulation Of Cytoskeleton Organization Regulation Of Cellular Response To Heat Platelet Activation Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Toxin Transport Binding Of Sperm To Zona Pellucida Positive Regulation Of Dephosphorylation Regulation Of Body Fluid Levels Sperm-egg Recognition Wound Healing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of MAPK Cascade Regulation Of DNA-templated Transcription In Response To Stress Muscle System Process 'de Novo' Posttranslational Protein Folding Actin Filament-based Process Histone H2B Acetylation Positive Regulation Of Phospholipid Scramblase Activity Skeletal Muscle Hypertrophy Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process ERBB2-ERBB3 Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Primary Spermatocyte Growth 'de Novo' Protein Folding Developmental Process Cellular Response To Heat Cell Activation Cell-cell Recognition Termination Of Signal Transduction Response To Wounding Rhythmic Process Platelet Degranulation Negative Regulation Of Actin Filament Polymerization Regulation Of Cellular Component Size Positive Regulation Of Type I Interferon Production Positive Regulation Of Phospholipid Catabolic Process Glucosylceramide Catabolic Process ERBB2 Signaling Pathway	Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Vitamin D Metabolic Process Actin-myosin Filament Sliding Muscle Filament Sliding Muscle Contraction Actin-mediated Cell Contraction Muscle System Process Actin Filament-based Movement Receptor-mediated Endocytosis Myofibril Assembly Tissue Development Skeletal Muscle Fiber Adaptation Positive Regulation Of Type IIa Hypersensitivity Cell Development Response To External Stimulus Anatomical Structure Formation Involved In Morphogenesis Actomyosin Structure Organization Vitamin Metabolic Process Positive Regulation Of Activation Of Membrane Attack Complex Insulin Receptor Signaling Pathway Striated Muscle Cell Development Lipid Metabolic Process Glomerular Mesangial Cell Development Regulation Of Phosphorylation Muscle Cell Development Cobalamin Transport Mesangial Cell Development Positive Regulation Of Hypersensitivity Endocytosis Renal Interstitial Fibroblast Development Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Histone H2B Ubiquitination Skeletal Muscle Adaptation Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus
Tagcloud ?		attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim	absent agglutinin bcr bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Difference) ?		attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim	absent agglutinin bcr bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Intersection) ?