GC and SERF2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GC	SERF2
Gene Name		group-specific component (vitamin D binding protein)	small EDRK-rich factor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Lysosomal Lumen Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytosol
	Molecular Function	Actin Binding Vitamin D Binding Vitamin Transporter Activity Calcidiol Binding	Molecular_function
	Biological Process	Steroid Metabolic Process Vitamin D Metabolic Process Small Molecule Metabolic Process Vitamin Transport	Biological_process
Pathways		Metabolism of lipids and lipoproteins Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism
Drugs
Diseases
GWAS		Metabolite levels ( 22916037) Non-alcoholic fatty liver disease histology (other) ( 23213074) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 22673963 20418485)
Protein-Protein Interactions		12 interactors: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 LRIF1 LRP2 PIK3R3 SERF2	15 interactors: BOLL CHD3 DAB1 GC KRTAP10-3 MDFI NELFCD PSMA3 PSME3 QKI RBPMS RHOXF2 SP4 THAP1 UPF2
Entrez ID		2638	10169
HPRD ID		00749	05447
Ensembl ID		ENSG00000145321
Uniprot IDs		P02774	P84101
PDB IDs		1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Vitamin D Metabolic Process Actin-myosin Filament Sliding Muscle Filament Sliding Muscle Contraction Actin-mediated Cell Contraction Muscle System Process Actin Filament-based Movement Receptor-mediated Endocytosis Myofibril Assembly Tissue Development Skeletal Muscle Fiber Adaptation Positive Regulation Of Type IIa Hypersensitivity Cell Development Response To External Stimulus Anatomical Structure Formation Involved In Morphogenesis Actomyosin Structure Organization Vitamin Metabolic Process Positive Regulation Of Activation Of Membrane Attack Complex Insulin Receptor Signaling Pathway Striated Muscle Cell Development Lipid Metabolic Process Glomerular Mesangial Cell Development Regulation Of Phosphorylation Muscle Cell Development Cobalamin Transport Mesangial Cell Development Positive Regulation Of Hypersensitivity Endocytosis Renal Interstitial Fibroblast Development Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Histone H2B Ubiquitination Skeletal Muscle Adaptation Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Gene Expression Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Regulation Of Cellular Process DNA Damage Response, Signal Transduction By P53 Class Mediator RNA Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cerebellum Structural Organization 3'-UTR-mediated MRNA Destabilization Glucosylceramide Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint
Tagcloud ?		absent agglutinin bcr bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Difference) ?		absent agglutinin bcr bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Intersection) ?