PXN and ITGA9

Number of citations of the paper that reports this interaction (PMID 11598204)
30

Data Source:
HPRD (in vitro, in vivo)

		PXN	ITGA9
Gene Name		paxillin	integrin, alpha 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Plasma Membrane Integrin Complex Basal Plasma Membrane Integrin Alpha9-beta1 Complex
	Molecular Function	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding	Collagen Binding Laminin Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway	Cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Extracellular Matrix Organization Neutrophil Chemotaxis Wound Healing
Pathways		Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Signal transduction by L1 Axon guidance ECM proteoglycans L1CAM interactions Integrin cell surface interactions
Drugs
Diseases
GWAS			Nasopharyngeal carcinoma ( 19478819) Phospholipid levels (plasma) ( 22359512) PR interval ( 23139255)
Protein-Protein Interactions		73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1	5 interactors: FIGF ITGB1 PXN SAT1 SPP1
Entrez ID		5829	3680
HPRD ID		03937	04910
Ensembl ID		ENSG00000089159
Uniprot IDs		E7EMK8 F5GZ78 P49023	Q13797 Q8N6H6
PDB IDs		1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion	Response To Vitamin D Angiogenesis Blood Vessel Morphogenesis Blood Vessel Development Maternal Process Involved In Female Pregnancy Vasculature Development Chemotaxis Response To Vitamin Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Projection Organization Multicellular Organismal Development Anatomical Structure Development Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Spermidine Acetylation Cell-matrix Adhesion Cardiovascular System Development Anatomical Structure Morphogenesis Response To Hormone Putrescine Catabolic Process Regulation Of Collagen Catabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Neuron Differentiation Regulation Of Cell-substrate Adhesion Cell Junction Assembly Developmental Process Cell-substrate Adhesion Cell-cell Junction Organization Response To Nutrient Positive Regulation Of Mast Cell Chemotaxis Calcium-independent Cell-matrix Adhesion Anatomical Structure Formation Involved In Morphogenesis Leukocyte Migration Female Pregnancy Oxalate Transport Formation Of Radial Glial Scaffolds Cell Adhesion Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Locomotion Negative Regulation Of Collateral Sprouting Negative Regulation Of Neurogenesis Negative Regulation Of Axon Regeneration Cell-cell Adhesion Mediated By Integrin Cellular Response To Stimulus Positive Regulation Of Cell Migration Negative Regulation Of Cell Development Positive Regulation Of Cell Motility
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Intersection) ?