PXN and AHCY

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PXN	AHCY
Gene Name		paxillin	adenosylhomocysteinase
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Nucleus Cytoplasm Cytosol Melanosome Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding	Adenosylhomocysteinase Activity Adenyl Nucleotide Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway	Sulfur Amino Acid Metabolic Process Response To Hypoxia Chronic Inflammatory Response To Antigenic Stimulus One-carbon Metabolic Process Xenobiotic Metabolic Process Response To Nutrient S-adenosylhomocysteine Catabolic Process Methylation S-adenosylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Circadian Sleep/wake Cycle Small Molecule Metabolic Process Homocysteine Biosynthetic Process
Pathways		Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Nicotinamide-Adenine-Dinucleotide (1\'r,2\'s)-9-(2-Hydroxy-3\'-Keto-Cyclopenten-1-Yl)Adenine 3\'-Oxo-Adenosine D-Eritadenine
Diseases
GWAS
Protein-Protein Interactions		73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1	7 interactors: ANKRD40 APPBP2 C1orf50 POT1 PXN TERF1 YWHAQ
Entrez ID		5829	191
HPRD ID		03937	01621
Ensembl ID		ENSG00000089159	ENSG00000101444
Uniprot IDs		E7EMK8 F5GZ78 P49023	P23526
PDB IDs		1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN	1A7A 1LI4 3NJ4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of Organelle Organization Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Component Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Organelle Organization Regulation Of Chromosome Organization Telomere Capping Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase DNA Replication Replicative Cell Aging Negative Regulation Of Transferase Activity Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Biosynthetic Process Positive Regulation Of Microtubule Polymerization Signal Complex Assembly Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Microtubule Polymerization Focal Adhesion Assembly Positive Regulation Of Transferase Activity Cellular Component Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx
Tagcloud (Intersection) ?