MTA3 and BCL6

Number of citations of the paper that reports this interaction (PMID 15454082)
84

Data Source:
BioGRID (pull down, imaging technique)

		MTA3	BCL6
Gene Name		metastasis associated 1 family, member 3	B-cell CLL/lymphoma 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleus Replication Fork
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Regulation Of Rho GTPase Activity Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Positive Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Cellular Senescence
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS			B cell non-Hodgkin lymphoma ( 23749188) PR interval ( 23534349) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		6 interactors: ARNT BCL6 ESR1 GRB2 KDM1A NACC2	44 interactors: AES BCL11A BCL6B BCOR BLZF1 CDK19 CDK8 CHD3 CREBBP CUTC EP300 FBXO11 HDAC4 HDAC5 HDAC7 HDAC9 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MED17 MED6 MTA3 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 TRAF1 WNK4 ZBTB16 ZBTB7A ZBTB7B
Entrez ID		57504	604
HPRD ID		12359	00180
Ensembl ID		ENSG00000057935	ENSG00000113916
Uniprot IDs		E7EQY4 Q9BTC8	B5B0A5 P41182
PDB IDs			1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Positive Regulation Of Hormone Biosynthetic Process Regulation Of Signaling Regulation Of Cell Proliferation Positive Regulation Of Erythrocyte Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Hormone Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Immune System Process Regulation Of Hormone Metabolic Process Regulation Of Erythrocyte Differentiation Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signaling Single Organism Reproductive Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Immune System Process Reproductive Process Negative Regulation Of Gene Expression Positive Regulation Of Myeloid Cell Differentiation Reproductive Structure Development Organ Development Reproductive System Development In Utero Embryonic Development Regulation Of Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Death RNA Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Primitive Erythrocyte Differentiation Chromatin Modification Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Embryonic Placenta Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Cellular Macromolecule Biosynthetic Process Cell Development Macromolecule Biosynthetic Process Chromatin Organization Developmental Process Involved In Reproduction Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Hemopoiesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Immune System Development Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Immune System Process DNA-templated Transcription, Initiation Response To Organic Substance Leukocyte Differentiation Chromatin Modification Cellular Protein Modification Process Developmental Process Nitrogen Compound Metabolic Process Organ Development Chromosome Organization
Tagcloud ?		adds aggressive axis claudin clinicopathological cohorts depicted determining dfs diminished diminution discovered downregulated drives ductal emt lowest mesenchymal operable partly progesterone raf registered rkip shorter sized snail subtype subtyping	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		adds aggressive axis claudin clinicopathological cohorts depicted determining dfs diminished diminution discovered downregulated drives ductal emt lowest mesenchymal operable partly progesterone raf registered rkip shorter sized snail subtype subtyping	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?