AMIGO1 and AMIGO2

Number of citations of the paper that reports this interaction (PMID 12629050)
18

Data Source:
HPRD (in vivo, in vitro)

		AMIGO1	AMIGO2
Gene Name		adhesion molecule with Ig-like domain 1	adhesion molecule with Ig-like domain 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon	Nucleus Plasma Membrane Integral Component Of Membrane
	Molecular Function		Protein Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axonogenesis Axonal Fasciculation Brain Development Myelination Positive Regulation Of Axonogenesis Cell-cell Adhesion	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Brain Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell-cell Adhesion
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146)	Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		2 interactors: AMIGO2 AMIGO3	3 interactors: AMIGO1 AMIGO3 CACNA1A
Entrez ID		57463	347902
HPRD ID		11129	16483
Ensembl ID		ENSG00000181754	ENSG00000139211
Uniprot IDs		Q86WK6	Q86SJ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Brain Development Head Development Central Nervous System Development Cell Adhesion Nervous System Development Organ Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Brain Development Head Development Central Nervous System Development Cerebellar Molecular Layer Development Regulation Of Axonogenesis Vestibular Nucleus Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Musculoskeletal Movement, Spinal Reflex Action Cerebellum Maturation Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Regulation Of Neuron Projection Development Nervous System Development Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Negative Regulation Of Hormone Biosynthetic Process Pons Development Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cerebellar Purkinje Cell Differentiation Organ Development Neuron Projection Morphogenesis Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Neurogenesis Reflex Cell Morphogenesis Involved In Differentiation Behavioral Response To Pain Neuromuscular Synaptic Transmission Axonal Fasciculation Regulation Of Hormone Biosynthetic Process Cerebellar Cortex Formation Neuron Projection Development Neurotransmitter Metabolic Process Cell Projection Morphogenesis Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Regulation Of Cell Development Cell Part Morphogenesis Calcium Ion Import Regulation Of Hormone Metabolic Process Cerebellar Purkinje Cell Layer Development Membrane Depolarization During Action Potential Neuron Recognition
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