PROX1 and LBH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PROX1	LBH
Gene Name		prospero homeobox 1	limb bud and heart development
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Transcription Regulatory Region DNA Binding DBD Domain Binding LBD Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Transcription From RNA Polymerase II Promoter Brain Development Circadian Rhythm Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Optic Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Transcription, DNA-templated Multicellular Organismal Development Regulation Of Gene Expression Regulation Of Blood Coagulation Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HIV-1 progression ( 20064070) Obesity ( 23818313)	Celiac disease and Rheumatoid arthritis ( 21383967) Height ( 18391951) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		17 interactors: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	1 interactors: PROX1
Entrez ID		5629	81606
HPRD ID		03330	13965
Ensembl ID		ENSG00000117707	ENSG00000213626
Uniprot IDs		Q92786	Q53QV2
PDB IDs		2LMD
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Cellular Response To Lipid Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Lipid Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Hormone Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Signal Transduction Involved In Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Response To Hypoxia Signal Transduction	Hepatocyte Cell Migration Positive Regulation Of Forebrain Neuron Differentiation Hepatocyte Proliferation Branching Involved In Pancreas Morphogenesis Acinar Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Otic Placode Formation Aorta Smooth Muscle Tissue Morphogenesis Pancreas Morphogenesis Liver Morphogenesis Endocardium Formation Positive Regulation Of Sarcomere Organization Lens Fiber Cell Morphogenesis Regulation Of Forebrain Neuron Differentiation Skeletal Muscle Thin Filament Assembly Negative Regulation Of Bile Acid Biosynthetic Process Olfactory Placode Formation Skeletal Myofibril Assembly Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Lymphatic Endothelial Cell Differentiation Optic Placode Formation Involved In Camera-type Eye Formation Positive Regulation Of Cell Cycle Checkpoint Optic Placode Formation Endocardium Morphogenesis Venous Blood Vessel Morphogenesis Otic Vesicle Formation Cerebellar Granule Cell Differentiation Lymphangiogenesis Otic Vesicle Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Bile Acid Biosynthetic Process Lymph Vessel Morphogenesis Regulation Of Sarcomere Organization Cerebellar Granular Layer Morphogenesis Hepatocyte Differentiation Dentate Gyrus Development Venous Blood Vessel Development Otic Vesicle Development Embryonic Camera-type Eye Formation Endocardium Development Lens Fiber Cell Development Ventricular Cardiac Muscle Cell Development Cerebellar Granular Layer Development Nose Development Lymph Vessel Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cardiac Myofibril Assembly Neuronal Stem Cell Maintenance Negative Regulation Of Steroid Biosynthetic Process
Tagcloud ?		allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole	antagonism bortezomib carboplatin clinically combinations curve cytotoxic deacetylase docetaxel downregulated doxorubicin enhancement exhibits gemcitabine markedly metformin multitude overexpressing pan panobinostat proteasome survivin synergism synergistic synergy triplet universal utility warranted
Tagcloud (Difference) ?		allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole	antagonism bortezomib carboplatin clinically combinations curve cytotoxic deacetylase docetaxel downregulated doxorubicin enhancement exhibits gemcitabine markedly metformin multitude overexpressing pan panobinostat proteasome survivin synergism synergistic synergy triplet universal utility warranted
Tagcloud (Intersection) ?