PROX1 and IRF4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PROX1	IRF4
Gene Name		prospero homeobox 1	interferon regulatory factor 4
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Transcription Regulatory Region DNA Binding DBD Domain Binding LBD Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-lysine N-methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Transcription From RNA Polymerase II Promoter Brain Development Circadian Rhythm Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Optic Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Transcription, DNA-templated Peptidyl-lysine Methylation Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HIV-1 progression ( 20064070) Obesity ( 23818313)	Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Celiac disease ( 20190752) Chronic lymphocytic leukemia ( 18758461) Eye color ( 20585627) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Hematology traits ( 23303382) Non-melanoma skin cancer ( 23548203) Progressive supranuclear palsy ( 21685912) Sunburns ( 23548203) Tanning ( 23548203)
Protein-Protein Interactions		17 interactors: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	19 interactors: BATF BCL6 ETV7 FKBP4 HOXB13 HOXC11 IKBKAP IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 YTHDC2
Entrez ID		5629	3662
HPRD ID		03330	03543
Ensembl ID		ENSG00000117707	ENSG00000137265
Uniprot IDs		Q92786	Q15306
PDB IDs		2LMD	2DLL
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Cellular Response To Lipid Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Lipid Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Hormone Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Signal Transduction Involved In Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Response To Hypoxia Signal Transduction	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cell Activation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Positive Regulation Of B Cell Activation Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Lymphocyte Activation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Cellular Nitrogen Compound Metabolic Process Cell Fate Commitment Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Developmental Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of B Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription T-helper Cell Lineage Commitment Negative Regulation Of RNA Biosynthetic Process Immune System Process Type 2 Immune Response Epithelial Cell Development CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Organ Development Lymphocyte Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response
Tagcloud ?		allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Difference) ?		allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Intersection) ?