MAPK6 and CNTRL

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		MAPK6	CNTRL
Gene Name		mitogen-activated protein kinase 6	centriolin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Cell Division
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	4 interactors: MAP3K4 MAPK6 TRADD UBC
Entrez ID		5597	11064
HPRD ID		04213	05691
Ensembl ID		ENSG00000069956	ENSG00000119397
Uniprot IDs		Q16659	Q7Z7A1
PDB IDs		2I6L
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated	MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Male Germ-line Sex Determination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Primary Sex Determination Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Protein Processing Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Chorionic Trophoblast Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chorion Development Apoptotic Signaling Pathway Positive Regulation Of P38MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Hair Follicle Development Viral Protein Processing Phosphorylation Intracellular Signal Transduction Response To UV-C Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Male Sex Determination Regulation Of P38MAPK Cascade Regulation Of Hair Follicle Development Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Transferase Activity Signaling Cellular Response To Cytokine Stimulus Cell Communication Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Hair Cycle Notch Receptor Processing
Tagcloud ?		astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging	ab abi animals bmd colitic colitis dosed dosing elastic experiment extrinsic femoral femur femurs fracture halted investigates mechanical modulus neutralizing noncolitic osteoblast osteoclast prophylactically resorption scl sclerostin ultimate worse
Tagcloud (Difference) ?		astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging	ab abi animals bmd colitic colitis dosed dosing elastic experiment extrinsic femoral femur femurs fracture halted investigates mechanical modulus neutralizing noncolitic osteoblast osteoclast prophylactically resorption scl sclerostin ultimate worse
Tagcloud (Intersection) ?