MAPK6 and CDH13

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAPK6	CDH13
Gene Name		mitogen-activated protein kinase 6	cadherin 13
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space Cytoplasm Plasma Membrane Caveola Focal Adhesion External Side Of Plasma Membrane Anchored Component Of Membrane Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity	Calcium Ion Binding Low-density Lipoprotein Particle Binding Protein Homodimerization Activity Cadherin Binding Adiponectin Binding Lipoprotein Particle Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Negative Regulation Of Cell Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Rac Protein Signal Transduction Lamellipodium Assembly Regulation Of Endocytosis Positive Regulation Of Cell Migration Cell Junction Assembly Adherens Junction Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelial Cell Migration Keratinocyte Proliferation Cell-cell Junction Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Positive Chemotaxis Localization Within Membrane Low-density Lipoprotein Particle Mediated Signaling
Pathways			Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS			Adiponectin levels ( 20876611 22479202 22065538 20887962 21771975) Attention deficit hyperactivity disorder ( 18839057) Blood pressure ( 17903302) D-dimer levels ( 21502573) Depression (quantitative trait) ( 20800221) Height ( 20189936) Hypertension ( 19304780) Response to amphetamines ( 22952603) Response to antipsychotic treatment ( 20195266) Response to fenofibrate (adiponectin levels) ( 23149075) Schizophrenia ( 23358160)
Protein-Protein Interactions		167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	2 interactors: ADIPOQ MAPK6
Entrez ID		5597	1012
HPRD ID		04213	03219
Ensembl ID		ENSG00000069956	ENSG00000140945
Uniprot IDs		Q16659	B7Z3H7 B7Z590 B7Z9B1 P55290
PDB IDs		2I6L	2V37
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated	Response To Linoleic Acid Positive Regulation Of Renal Albumin Absorption Detection Of Oxidative Stress Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Binding Negative Regulation Of Granulocyte Differentiation Adiponectin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Positive Regulation Of Myeloid Cell Apoptotic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Macrophage Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Heterotrimerization Negative Regulation Of Phagocytosis Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Gluconeogenesis Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Kinase A Signaling Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Receptor Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Migration Cellular Response To Epinephrine Stimulus Response To Sucrose Positive Regulation Of Cholesterol Efflux Response To Epinephrine Positive Regulation Of Cholesterol Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Cholesterol Efflux Negative Regulation Of DNA Biosynthetic Process Low-density Lipoprotein Particle Clearance Cellular Response To Catecholamine Stimulus Regulation Of Protein Autophosphorylation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Fatty Acid Metabolic Process Protein Trimerization Plasma Lipoprotein Particle Clearance
Tagcloud ?		astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging	almost alterations conclude cutaneous dapk1 elucidate epigenetic exclusively exposed finally hypermethylation hypomethylation lesional methylation neither normal perilesional protected repetitive represent samples scc sequence sequences skin squamous sun tissues trend
Tagcloud (Difference) ?		astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging	almost alterations conclude cutaneous dapk1 elucidate epigenetic exclusively exposed finally hypermethylation hypomethylation lesional methylation neither normal perilesional protected repetitive represent samples scc sequence sequences skin squamous sun tissues trend
Tagcloud (Intersection) ?